Long-term high-soybean oil feeding alters regulation of body temperature in rats.
Long-term high-soybean oil feeding alters regulation of body temperature in rats.
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长期高豆油喂养会改变大鼠的体温调节。
DOI：
10.1248/bpb.b13-00977
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发表时间：
2014
影响因子：
2
通讯作者：
H. Okuyama
中科院分区：
文献类型：
--
作者：
H. Tsushima;Kazuyo Yamada;D. Miyazawa;M. Mori;Y. Hashimoto;T. Ohkubo;H. Hibino;H. Okuyama
我们研究了饮食脂肪酸（FA）是否会影响体温（BT）调节机制。雄性Wistar大鼠喂饲高脂饲料，其中含有鱼油（HFD）、大豆油（HSD）或猪油（HLD）。干预20周时，HSD组和HLD组在光照和黑暗期的BT均低于正常饮食组。侧脑室注射白细胞介素-1 β和蛙皮素后，HSD组的体温升高程度明显高于ND组，而体温降低程度较ND组弱。HSD差异影响BT在生理和药理条件下。HSD组下丘脑中n-6/n-3FAs比值高于ND组。DNA微阵列显示，与ND组相比，HSD组下丘脑促甲状腺激素β亚基表达增加，多个基因表达减少。HSD喂养增加了血浆中几种脂肪因子的浓度。然而，只有HSD和HLD组在生理条件下表现出明显的低温，没有脂肪因子或基因表达发生变化。这些发现表明，长期摄入HSD会产生异常的BT调节。在HSD喂养后的生理条件下，脂肪因子或蛋白质/肽参与异常BT调节的可能性较小。
We investigated whether body temperature (BT) regulatory mechanisms are influenced by dietary fatty acids (FA). Male Wistar rats were fed a high-fat diet containing fish oil (HFD), soybean oil (HSD) or lard (HLD). At the 20-week intervention, the BT of the HSD and HLD groups were lower than that of the normal diet (ND) group in the light and dark periods. The intracerebroventricular injections of interleukin-1β and bombesin in the HSD group induced greater hyperthermia and weaker hypothermia, respectively, than in the ND group. The HSD differentially affected BT under both physiological and pharmacological conditions. In the hypothalamus, the ratio of n-6/n-3 FAs was higher in the HSD group compared with the ND group. DNA microarrays revealed increased expression of thyroid-stimulating hormone β-subunit, and decreased expression of several genes in the hypothalamus of the HSD group compared with the ND group. The HSD feeding increased several adipokine concentrations in the plasma. However, there were no adipokines or gene expressions that changed in only the HSD and HLD groups showing significant hypothermia under the physiological condition. These findings suggested that long-term HSD intake produces abnormal BT regulation. It is less likely that adipokines or proteins/peptides are involved in abnormal BT regulation under the physiological conditions after HSD feeding.
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影响因子：
4.8
作者：
Skibicka, Karolina P.;Grill, Harvey J.
通讯作者：
Grill, Harvey J.
影响因子：
5
作者：
McGuire, Blaine A.;Baladi, Michelle G.;France, Charles P.
通讯作者：
France, Charles P.
DOI：
10.1152/ajpendo.00448.2010
发表时间：
2010-09
期刊：
American journal of physiology. Endocrinology and metabolism
影响因子：
--
作者：
M. Perelló;I. Çakır;Nicole E. Cyr;A. Romero;R. Stuart;Franck Chiappini;A. Hollenberg;E. Nillni
通讯作者：
M. Perelló;I. Çakır;Nicole E. Cyr;A. Romero;R. Stuart;Franck Chiappini;A. Hollenberg;E. Nillni
影响因子：
3.4
作者：
Chapkin, Robert S.;Wang, Naisyin;Prior, Ian A.
通讯作者：
Prior, Ian A.
影响因子：
4.4
作者：
Chen, Weiqin;Jump, Donald B.;Busik, Julia V.
通讯作者：
Busik, Julia V.