Eating high-fat chow enhances sensitization to the effects of methamphetamine on locomotion in rats.
Eating high-fat chow enhances sensitization to the effects of methamphetamine on locomotion in rats.
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DOI：
10.1016/j.ejphar.2011.02.027
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发表时间：
2011-05-11
影响因子：
5
通讯作者：
France, Charles P.
中科院分区：
文献类型：
--
作者：
McGuire, Blaine A.;Baladi, Michelle G.;France, Charles P.
吃高脂肪食物可以改变直接或间接作用于多巴胺系统的药物的作用，并且重复间歇性给药可以显著增加敏感性（即，致敏）对间接作用多巴胺受体激动剂的行为效应（例如，甲基苯丙胺）。本研究探讨是否吃高脂肪的食物改变敏感性的雄性Sprague道利大鼠急性或重复给药的甲基苯丙胺的运动刺激作用。甲基苯丙胺对运动的急性影响在进食高脂肪或标准食物1周或4周的大鼠（n=6/组）之间没有差异。对甲基苯丙胺（0.1-10 mg/kg，i. p.）在4次每周一次的试验中逐渐增加;与食用标准食物的大鼠相比，食用高脂肪食物的大鼠中这种致敏作用发展得更快，程度更大。因此，虽然吃高脂肪食物似乎不会改变大鼠对急性给药甲基苯丙胺的敏感性，但它显著增加了对重复间歇给药甲基苯丙胺的致敏作用。这些数据表明，吃某些食物会影响对作用于多巴胺系统的药物的敏感性的发展。
Eating high-fat chow can modify the effects of drugs acting directly or indirectly on dopamine systems and repeated intermittent drug administration can markedly increase sensitivity (i.e., sensitization) to the behavioral effects of indirect-acting dopamine receptor agonists (e.g., methamphetamine). This study examined whether eating high-fat chow alters the sensitivity of male Sprague Dawley rats to the locomotor stimulating effects of acute or repeated administration of methamphetamine. The acute effects of methamphetamine on locomotion were not different between rats (n=6/group) eating high-fat or standard chow for 1 or 4 weeks. Sensitivity to the effects of methamphetamine (0.1–10 mg/kg, i.p.) increased progressively across 4 once per week tests; this sensitization developed more rapidly and to a greater extent in rats eating high-fat chow as compared with rats eating standard chow. Thus, while eating high-fat chow does not appear to alter sensitivity of rats to acutely-administered methamphetamine, it significantly increases the sensitization that develops to repeated intermittent administration of methamphetamine. These data suggest that eating certain foods influences the development of sensitization to drugs acting on dopamine systems.
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影响因子：
5
作者：
Sevak, Rajkumar J.;Koek, Wouter;Owens, William Anthony;Galli, Aurelio;Daws, Lynette C.;France, Charles P.
通讯作者：
France, Charles P.
影响因子：
2.5
作者：
Amano, T;Matsubayashi, H;Sakai, N
通讯作者：
Sakai, N
影响因子：
2.3
作者：
Seeman, P;Tallerico, T;Kapur, S
通讯作者：
Kapur, S
影响因子：
3.4
作者：
Shuto, Takahide;Seeman, Philip;Nishi, Akinori
通讯作者：
Nishi, Akinori
影响因子：
4.4
作者：
South, Timothy;Huang, Xu-Feng
通讯作者：
Huang, Xu-Feng