The Beneficial Effect of Praeruptorin C on Osteoporotic Bone in Ovariectomized Mice via Suppression of Osteoclast Formation and Bone Resorption.
The Beneficial Effect of Praeruptorin C on Osteoporotic Bone in Ovariectomized Mice via Suppression of Osteoclast Formation and Bone Resorption.
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Praeruptorin C 通过抑制破骨细胞形成和骨吸收对去卵巢小鼠骨质疏松骨的有益作用
DOI：
10.3389/fphar.2017.00627
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发表时间：
2017
影响因子：
5.6
通讯作者：
Dai M
中科院分区：
文献类型：
--
作者：
Liu X;Chin JF;Qu X;Bi H;Liu Y;Yu Z;Zhai Z;Qin A;Zhang B;Dai M
骨质疏松症是一种非常普遍的疾病，它会导致代谢缺陷。骨密度低，骨强度受损，脆性骨折的危险增加是其主要特征。天然化合物已被认为是治疗骨质疏松症的潜在替代治疗剂。在这项研究中，我们证明了一种天然化合物praproctorin C (Pra-C)，从praproctorum的干燥根中提取，通过减弱核因子κ B的激活以及C - jun n末端激酶/丝裂原激活的蛋白激酶信号通路，具有抑制破骨细胞形成和吸收功能的有益作用。此外，我们在卵巢切除（OVX）小鼠（一种成熟的绝经后骨质流失模型）中对Pra-C进行了测试，结果表明，Pra-C对抑制OVX小鼠过度的破骨细胞活性和增加骨量具有有益的作用。因此，Pra-C对OVX小鼠骨的保护作用与其抑制破骨细胞形成和骨吸收有关，提示Pra-C是治疗骨质疏松症的潜在候选药物。
Being a highly prevalent disease, osteoporosis causes metabolism defects. Low bone density, compromised bone strength, and an increased danger of fragility fracture are its main characteristics. Natural compounds have been considered as potential alternative therapeutic agents for treating osteoporosis. In this study, we demonstrated that a natural compound, praeruptorin C (Pra-C), derived from the dried roots ofPeucedanum praeruptorum, has beneficial effects in suppressing osteoclast formation and resorption function via attenuating the activation of nuclear factor kappa B as well as c-Jun N-terminal kinase/mitogen-activated protein kinase signaling pathways. Moreover, Pra-C was tested in the ovariectomized (OVX) mice, a well-established model of post-menopausal bone loss, and the results indicated Pra-C exerted beneficial effects on inhibiting excessive osteoclast activity and increasing bone mass of OVX mice. Therefore, the protective effects of Pra-C on OVX mice bone are related to its inhibition of osteoclast formation and bone resorption, suggesting that Pra-C is a good potential candidate for osteoporosis treatment.
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DOI：
10.1016/s0167-5699(00)01718-7
发表时间：
2000-10-01
期刊：
IMMUNOLOGY TODAY
影响因子：
--
作者：
Kong, YY;Boyle, WJ;Penninger, JM
通讯作者：
Penninger, JM
影响因子：
3.7
作者：
Moriwaki S;Suzuki K;Muramatsu M;Nomura A;Inoue F;Into T;Yoshiko Y;Niida S
通讯作者：
Niida S
影响因子：
3.5
作者：
Crotti, Tania N.;Flannery, Merrilee;McHugh, Kevin P.
通讯作者：
McHugh, Kevin P.
影响因子：
158.5
作者：
Barrett-Connor, Elizabeth;Mosca, Lori;Wenger, Nanette K.
通讯作者：
Wenger, Nanette K.
影响因子：
11.4
作者：
Kobayashi, N;Kadono, Y;Inoue, J
通讯作者：
Inoue, J