BDNF mediates the protective effects of scopolamine in reserpine-induced depression-like behaviors via up-regulation of 5-HTT and TPH1
BDNF mediates the protective effects of scopolamine in reserpine-induced depression-like behaviors via up-regulation of 5-HTT and TPH1
复制标题
BDNF 通过上调 5-HTT 和 TPH1 介导东莨菪碱对利血平诱导的抑郁样行为的保护作用
DOI：
10.1016/j.psychres.2018.12.015
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发表时间：
2019-01
影响因子：
11.3
通讯作者：
Wang Chuang
中科院分区：
文献类型：
--
作者：
Yu Hanjie;Lv Dan;Shen Mengxin;Zhang Yanhua;Zhou Dongsheng;Chen Zhongming;Wang Chuang
Reserpine treatment in rodents has been shown to induce depression-like behaviors that mimic monoamine dysfunction implicated in the development of depression. Herein, we aimed to demonstrate the antidepressant-like activities of scopolamine, the muscarinic receptor antagonist, in a reserpine-induced mouse model. Mice were injected with 1.5 mg/kg (i.p.) of reserpine for 10 days, and the depression-like state was confirmed via the open field test (OFT) and forced swimming test (FST). Then, the mice were treated with scopolamine (25 µg/kg, i.p.) or saline for 3 days. Ten days of reserpine treatment resulted in a significant decrease in locomotor activity and an increase in immobility time in the OFT and FST, respectively, indicating that ten days of reserpine administration significantly induced depression-like behaviors in mice. However, scopolamine rapidly ameliorated the increase in immobility time in the FST and had no effect on locomotor activity in the OFT. In addition, the reserpine-induced decreases in serotonin transporter (5-HTT), brain-derived neurotrophic factor (BDNF) and tryptophan hydroxylase 1 (TPH1) in mouse hippocampus and prefrontal cortex (PFC) were significantly reversed by scopolamine. Our study provides evidence that scopolamine rapidly attenuates reserpine-induced depression in mice partially by regulating 5-HTT, BDNF and TPH1 in the hippocampus and PFC of mice.
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影响因子：
0.8
作者：
H. Ikram;D. Haleem
通讯作者：
H. Ikram;D. Haleem
影响因子：
2.3
作者：
Newberg, Andrew B.;Amsterdam, Jay D.;Wintering, Nancy;Shults, Justine
通讯作者：
Shults, Justine
影响因子：
10.6
作者：
Gizatullin, R;Zaboli, G;Leopardi, R
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Leopardi, R
影响因子：
6.6
作者：
Kerling, A.;Kueck, M.;Kahl, K. G.
通讯作者：
Kahl, K. G.
影响因子：
4.7
作者：
Daws, L. C.;Munn, J. L.;Hensler, J. G.
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Hensler, J. G.