Association between TNF-a promoter -308G/A polymorphism and essential hypertension in the Asian population: A meta-analysis.
Association between TNF-a promoter -308G/A polymorphism and essential hypertension in the Asian population: A meta-analysis.
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亚洲人群中 TNF-a 启动子 308G/A 多态性与原发性高血压之间的关联：荟萃分析
DOI：
10.1177/1470320317741066
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发表时间：
2017-10
期刊：
影响因子：
--
通讯作者：
Jin YL
中科院分区：
文献类型：
--
作者：
Yao YS;Chang WW;Jin YL
关于肿瘤坏死因子-a -308G/A (TNF-a -308G/A) 多态性与原发性高血压易感性之间关系的研究结果存在争议。为了获得更精确的估计，我们对所有类似文章进行了荟萃分析。获得了总结效应比值比和 95% 置信区间。漏斗图和 Egger 检验用于估计发表偏倚，异质性通过基于卡方的 Q 检验和 I2 检验进行评估。纳入了 9 项研究（1437 例病例和 1487 例对照）。总体分析中，综合结果显示，原发性高血压病例和对照、AA+GA 与 GG 之间的基因型分布存在显着差异（OR = 1.53，95% CI：1.25–1.88，p<0.00001）。在按国家分层分析中，我们发现亚洲人群中原发性高血压病例的 AA+GA 与 GG 发生率显着高于对照组（OR = 1.47，95% CI：1.18–1.81，p = 0.0004）。这项荟萃分析支持了之前的发现，即 TNF-a -308G/A 多态性可能会增加原发性高血压的风险，至少在亚洲人群中是这样。
The results of studies on the association between tumor necrosis factor-a -308G/A (TNF-a -308G/A) polymorphism, and susceptibility to essential hypertension are controversial. To derive a more precise estimation, we conducted a meta-analysis of all similar articles. The summary effect odds ratios and 95% confidence intervals were obtained. Funnel plots and Egger’s test were used to estimate publication bias, and heterogeneity was assessed by the chi-square-based Q-test and I2 test. Nine studies (with 1437 cases and 1487 controls) were included. In the overall analysis, the combined results showed that there were significant differences in genotype distribution between essential hypertension cases and controls, AA+GA versus GG (OR = 1.53, 95% CI: 1.25–1.88, p < 0.00001). In the stratified analysis by country, we found that essential hypertension cases had a significantly higher frequency of AA+GA versus GG (OR = 1.47, 95% CI: 1.18–1.81, p = 0.0004) than control in the Asian population. This meta-analysis supports previous findings that TNF-a -308G/A polymorphism may increase the risk of essential hypertension, at least in the Asian population.
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影响因子：
9.3
作者：
Dange RB;Agarwal D;Teruyama R;Francis J
通讯作者：
Francis J
DOI：
10.1073/pnas.94.7.3195
发表时间：
1997-04-01
影响因子：
11.1
作者：
Wilson, AG;Symons, JA;Duff, GW
通讯作者：
Duff, GW
影响因子：
2.3
作者：
Okura, Takafumi;Jotoku, Masanori;Higaki, Jitsuo
通讯作者：
Higaki, Jitsuo
影响因子：
5.6
作者：
Briet, Marie;Schiffrin, Ernesto L.
通讯作者：
Schiffrin, Ernesto L.
影响因子：
2.7
作者：
Bautista, LE;Vera, LM;Gamarra, G
通讯作者：
Gamarra, G