Left ventricular hypertrophy and cardiovascular mortality by race and ethnicity.
Left ventricular hypertrophy and cardiovascular mortality by race and ethnicity.
复制标题
左心室肥大和种族和种族的心血管死亡率。
DOI：
10.1016/j.amjmed.2008.05.034
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发表时间：
2008-10
影响因子：
5.9
通讯作者：
Steiner, John F.
中科院分区：
文献类型：
--
作者：
Havranek, Edward P.;Froshaug, Desiree B.;Emserman, Caroline D. B.;Hanratty, Rebecca;Krantz, Mori J.;Masoudi, Frederick A.;Dickinson, L. Miriam;Steiner, John F.
关键词：
左心室肥厚是心血管死亡的主要独立危险因素。左心室肥大对心血管死亡率的种族差异的影响尚不清楚。我们使用来自第三次全国健康和营养检查调查和国家死亡指数的数据，分别比较了白人、非洲裔美国人和拉丁裔人中心电图（ECG）诊断为左心室肥大和无左心室肥大的患者的死亡率。我们使用考克斯比例风险回归来控制其他已知的预后因素。在所有三个种族/民族中，心电图左心室肥大与十年心血管死亡率显着相关，无论是未经调整还是根据其他已知预后因素调整。与收缩压无关，非裔美国人（2.31，95% CI 1.55-3.42）的风险比显著高于白人和拉丁美洲人（分别为1.32，95% CI 1.14-1.76和2.11，95% CI 1.35-3.30）。心电图左心室肥大对非裔美国人心血管死亡风险的贡献大于白人。使用心电图左心室肥厚的回归作为治疗目标可能是减少心血管死亡率种族差异的一种手段;需要前瞻性验证。
Left ventricular hypertrophy is a major independent risk factor for cardiovascular mortality. The contribution of left ventricular hypertrophy to racial and ethnic differences in cardiovascular mortality is poorly understood. We used data from the Third National Health and Nutrition Examination Survey and from the National Death Index to compare mortality for those with an electrocardiographic (ECG) diagnosis of left ventricular hypertrophy to those without left ventricular hypertrophy separately for whites, African Americans, and Latinos. We used Cox proportional hazards regression to control for other known prognostic factors. ECG left ventricular hypertrophy was significantly associated with ten-year cardiovascular mortality in all three racial/ethnic groups, both unadjusted and adjusted for other known prognostic factors. The hazard ratio for this association was significantly greater for African Americans (2.31, 95% CI 1.55–3.42) than for whites and Latinos (1.32, 95% CI 1.14–1.76 and 2.11, 95% CI 1.35–3.30 respectively) independent of systolic blood pressure. ECG left ventricular hypertrophy contributes more to the risk of cardiovascular mortality in African Americans than it does in Whites. Using regression of ECG left ventricular hypertrophy as a goal of therapy might be a means to reduce racial differences in cardiovascular mortality; prospective validation is required.
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影响因子：
8.3
作者：
Drazner, MH;Dries, DL;Victor, RG
通讯作者：
Victor, RG
DOI：
10.1016/s0735-1097(02)03006-1
发表时间：
2003-03-19
影响因子：
24
作者：
East, MA;Jollis, JG;Peterson, ED
通讯作者：
Peterson, ED
影响因子：
37.8
作者：
LEVY, D;SALOMON, M;KANNEL, WB
通讯作者：
KANNEL, WB
影响因子：
2.7
作者：
Perez, M. V.;Yaw, T. S.;Froelicher, V. F.
通讯作者：
Froelicher, V. F.
影响因子：
3.2
作者：
Chapman, JN;Mayet, J;Poulter, NR
通讯作者：
Poulter, NR