A bio-telemetric device for measurement of left ventricular pressure-volume loops using the admittance technique in conscious, ambulatory rats.
A bio-telemetric device for measurement of left ventricular pressure-volume loops using the admittance technique in conscious, ambulatory rats.
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DOI：
10.1088/0967-3334/32/6/007
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发表时间：
2011-06
影响因子：
3.2
通讯作者：
Valvano JW
中科院分区：
文献类型：
--
作者：
Raghavan K;Feldman MD;Porterfield JE;Larson ER;Jenkins JT;Escobedo D;Pearce JA;Valvano JW
This paper presents the design, construction and testing of a device to measure pressure volume loops in the left ventricle of conscious, ambulatory rats. Pressure is measured with a standard sensor, but volume is derived from data collected from a tetrapolar electrode catheter using a novel admittance technique. There are two main advantages of the admittance technique to measure volume. First, the contribution from the adjacent muscle can be instantaneously removed. Second, the admittance technique incorporates the nonlinear relationship between the electric field generated by the catheter and the blood volume. A low power instrument weighing 27 g was designed, which takes pressure-volume loops every 2 minutes and runs for 24 hours. Pressure-volume data are transmitted wirelessly to a base station. The device was first validated in thirteen rats with an acute preparation with 2-D echocardiography used to measure true volume. From an accuracy standpoint, the admittance technique is superior to both the conductance technique calibrated with hypertonic saline injections, and calibrated with cuvettes. The device was then tested in six rats with a 24-hour chronic preparation. Stability of the animal preparation and careful calibration are important factors affecting the success of the device.
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DOI：
10.1152/ajpheart.2000.279.4.h1698
发表时间：
2000-10-01
影响因子：
4.8
作者：
Feldman, MD;Erikson, JM;Freeman, GL
通讯作者：
Freeman, GL
DOI：
10.1152/ajpheart.00035.2004
发表时间：
2004-12-01
影响因子：
4.8
作者：
Uemura, K;Kawada, T;Sunagawa, K
通讯作者：
Sunagawa, K
影响因子：
4.6
作者：
Raghavan, Karthik;Porterfield, John E.;Pearce, John A.
通讯作者：
Pearce, John A.
影响因子：
10.8
作者：
BAAN, J;JONG, TTA;KOOPS, J
通讯作者：
KOOPS, J
影响因子：
--
作者：
LANKFORD, EB;KASS, DA;SHOUKAS, MA
通讯作者：
SHOUKAS, MA