Analysis of promoter polymorphism in monoamine oxidase A (MAOA) gene in completed suicide on Slovenian population
Analysis of promoter polymorphism in monoamine oxidase A (MAOA) gene in completed suicide on Slovenian population
复制标题
斯洛文尼亚人群自杀事件中单胺氧化酶A（MAOA）基因启动子多态性分析
DOI：
10.1016/j.neulet.2018.02.063
复制
发表时间：
2018
影响因子：
2.5
通讯作者：
Alja Videtič Paska
中科院分区：
文献类型：
--
作者：
K. Uršič;T. Zupanc;Alja Videtič Paska
自杀是一个定义明确的公共卫生问题，是一个受许多不同风险因素影响的复杂现象，包括遗传因素。许多研究已经检查了血清素系统基因。单胺氧化酶A（MAO-A）是一种线粒体外膜酶，参与5-羟色胺降解的代谢途径。MAOA基因启动子区上游可变数目串联重复序列（uVNTR）影响转录活性。在本研究中，我们对266名自杀者和191名对照组的斯洛文尼亚人进行了MAOA-uVNTR多态性的基因分型，斯洛文尼亚人是欧洲和世界上自杀率最高的人群之一。用聚合酶链反应和琼脂糖凝胶电泳进行基因分型。对女性和男性受试者进行单独的统计分析，我们确定了研究组之间MAOA-uVNTR多态性基因型分布的差异。统计学分析显示3R等位基因与自杀倾向呈显著正相关，分层资料（20例自杀者）显示3R等位基因与非暴力自杀方式相关。这是第一项将斯洛文尼亚高自杀率人群与MAOA-uVNTR多态性联系起来的研究。
Suicide is a well-defined public health problem and is a complex phenomenon influenced by a number of different risk factors, including genetic ones. Numerous studies have examined serotonin system genes. Monoamine oxidase A (MAO-A) is an outer mitochondrial membrane enzyme which is involved in the metabolic pathway of serotonin degradation. Upstream variable number of tandem repeats (uVNTR) in the promoter region ofMAOAgene affects the activity of transcription. In the present study we genotypedMAOA-uVNTR polymorphism in 266 suicide victims and 191 control subjects of Slovenian population, which ranks among the European and world populations with the highest suicide rate. Genotyping was performed with polymerase chain reaction and agarose gel electrophoresis. Using a separate statistical analysis for female and male subjects we determined the differences in genotype distributions ofMAOA-uVNTR polymorphism between the studied groups. Statistical analysis showed a trend towards 3R allele and suicide, and associated 3R allele with non-violent suicide method on stratified data (20 suicide victims). This is the first study associating highly suicidal Slovenian population withMAOA-uVNTR polymorphism.
影响因子：
6.8
作者：
Ziegler C;Richter J;Mahr M;Gajewska A;Schiele MA;Gehrmann A;Schmidt B;Lesch KP;Lang T;Helbig-Lang S;Pauli P;Kircher T;Reif A;Rief W;Vossbeck-Elsebusch AN;Arolt V;Wittchen HU;Hamm AO;Deckert J;Domschke K
通讯作者：
Domschke K
低活性 MAOA 等位基因变异与被监禁罪犯暴力犯罪的关联。
影响因子：
4.8
作者：
Stetler,DeanA;Davis,Chad;Leavitt,Kathryn;Schriger,Ilana;Benson,Katie;Bhakta,Samir;Wang,LamChee;Oben,Cynthia;Watters,Matthew;Haghnegahdar,Tara;Bortolato,Marco
通讯作者：
Bortolato,Marco
影响因子：
9.8
作者：
G. Hotamisligil;X. Breakefield
通讯作者：
G. Hotamisligil;X. Breakefield