Mahalanobis distance tractometry (MaD-Tract) - a framework for personalized white matter anomaly detection applied to TBI.
Mahalanobis distance tractometry (MaD-Tract) - a framework for personalized white matter anomaly detection applied to TBI.
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DOI：
10.1016/j.neuroimage.2022.119475
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发表时间：
2022-10-15
期刊：
影响因子：
5.7
通讯作者：
Alexander, Andrew L.
中科院分区：
文献类型：
--
作者：
Guerrero-Gonzalez, Jose M.;Yeske, Benjamin;Kirk, Gregory R.;Bell, Michael J.;Ferrazzano, Peter A.;Alexander, Andrew L.
基于磁共振扩散加权成像的定量测量(DMRI)提供了从人脑组织中非侵入性地提取微观信息的能力。对这些指标进行群体水平的比较是调查异常大脑状况的重要方法。当受试者的异常区域在空间上重合时，这些类型的分析特别有用。如果这不是真的，则有必要采用个性化分析的方法。在这里，我们提出了一个基于马氏距离的单主体多维分析框架。这是沿着特定的白质通路进行的，这些通路由纤维束造影术得到的流线束表示。根据Wilk标准构建了异常的定义，该标准考虑了标准样本量、马氏距离中使用的特征数量和多次比较。创伤性脑损伤(TBI)是一种在不同受试者之间表现出高度异质性的疾病。使用由扣带、钩状和穹隆部位的弥散张量的三个特征值计算的马氏距离，对8例重型颅脑损伤患者和49例健康对照进行了单独比较。对于所有的颅脑损伤患者，分析显示沿着分析束的一个或多个位置与标准数据有统计学上的显著偏差。检测到的异常广泛分布在分析的区域，与预期的不均质性一致，这是TBI的标志。每个控制组受试者也与控制组中的其余48个受试者以留一的方式进行比较。在对照组的整个分析中，只有两个节段被识别为异常，因此该方法也显示出良好的特异性。
Imaging-based quantitative measures from diffusion-weighted MRI (dMRI) offer the ability to non-invasively extract microscopic information from human brain tissues. Group-level comparisons of such measures represent an important approach to investigate abnormal brain conditions. These types of analyses are especially useful when the regions of abnormality spatially coincide across subjects. When this is not true, approaches for individualized analyses are necessary. Here we present a framework for single-subject multidimensional analysis based on the Mahalanobis distance. This is conducted along specific white matter pathways represented by tractography-derived streamline bundles. A definition for abnormality was constructed from Wilk’s criterion, which accounts for normative sample size, number of features used in the Mahalanobis distance, and multiple comparisons. One example of a condition exhibiting high heterogeneity across subjects is traumatic brain injury (TBI). Using the Mahalanobis distance computed from the three eigenvalues of the diffusion tensor along the cingulum, uncinate, and parcellated corpus callosum tractograms, 8 severe TBI patients were individually compared to a normative sample of 49 healthy controls. For all TBI patients, the analyses showed statistically significant deviations from the normative data at one or multiple locations along the analyzed bundles. The detected anomalies were widespread across the analyzed tracts, consistent with the expected heterogeneity that is hallmark of TBI. Each of the controls subjects was also compared to the remaining 48 subjects in the control group in a leave-one-out fashion. Only two segments were identified as abnormal out of the entire analysis in the control group, thus the method also demonstrated good specificity.
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