Quantifying excess mortality during the COVID-19 pandemic in 2020 in The Gambia: a time-series analysis of three health and demographic surveillance systems.

Quantifying excess mortality during the COVID-19 pandemic in 2020 in The Gambia: a time-series analysis of three health and demographic surveillance systems.
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DOI:
10.1016/j.ijid.2022.12.017
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发表时间:
2023-03
影响因子:
8.4
通讯作者:
Roca, Anna
Roca, Anna
中科院分区:
医学2区
文献类型:
--
作者:
Mohammed, Nuredin I.;Mackenzie, Grant;Ezeani, Esu;Sidibeh, Mamadi;Jammeh, Lamin;Sarwar, Golam;Saine, Aji Kumba Folawiyo;Sonko, Bakary;Gomez, Pierre;Dondeh, Bai Lamin;Hossain, M. Jahangir;Jasseh, Momodou;Usuf, Effua;Prentice, Andrew M.;Jeffries, David;Dalessandro, Umberto;Roca, Anna

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需要使用当地数据估算非洲人口与 COVID-19 相关的超额死亡率,以设计和实施有效的控制政策。我们利用来自冈比亚三个健康和人口监测系统(Basse、Farafenni 和 Keneba)的数据进行时间序列分析,以检查与大流行前时期(2016-2019 年)相比,2020 年(观察到第一波 SARS-CoV-2 浪潮)期间与大流行相关的超额死亡率。在这三个地点,大流行前时期的平均死亡率和 2020 年的总死亡人数分别为 1512 人和 1634 人(巴塞:1099 比 1179,法拉芬尼:316 比 351,凯内巴:98 比 104)。大流行前和 2020 年期间每 10 万人的年度总体粗死亡率 (95% CI) 分别为 589 (559, 619) 和 599 (571, 629)。调整后的超额死亡率为每 10 万人月 8.8 (-34.3, 67.6),调整后的比率 (aRR) = 1.01 (0.94,1.11)。年龄分层分析显示,巴斯的婴儿死亡率过高(aRR = 1.22 [1.04, 1.46]),法拉芬尼的 65 岁以上年龄组死亡率过高(aRR = 1.19 [1, 1.44])。我们没有发现冈比亚 2020 年总体死亡率显着超额。然而,某些年龄组可能面临过度死亡的风险。卫生系统薄弱的国家的公共卫生应对措施需要考虑弱势年龄群体和潜在的附带损害。
Estimates for COVID-19-related excess mortality for African populations using local data are needed to design and implement effective control policies. We applied time-series analysis using data from three health and demographic surveillance systems in The Gambia (Basse, Farafenni, and Keneba) to examine pandemic-related excess mortality during 2020, when the first SARS-CoV-2 wave was observed, compared to the pre-pandemic period (2016-2019). Across the three sites, average mortality during the pre-pandemic period and the total deaths during 2020 were 1512 and 1634, respectively (Basse: 1099 vs 1179, Farafenni: 316 vs 351, Keneba: 98 vs 104). The overall annual crude mortality rates per 100,000 (95% CI) were 589 (559, 619) and 599 (571, 629) for the pre-pandemic and 2020 periods, respectively. The adjusted excess mortality rate was 8.8 (-34.3, 67.6) per 100,000 person-month with the adjusted rate ratio (aRR) = 1.01 (0.94,1.11). The age-stratified analysis showed excess mortality in Basse for infants (aRR = 1.22 [1.04, 1.46]) and in Farafenni for the 65+ years age group (aRR = 1.19 [1, 1.44]). We did not find significant excess overall mortality in 2020 in The Gambia. However, some age groups may have been at risk of excess death. Public health response in countries with weak health systems needs to consider vulnerable age groups and the potential for collateral damage.
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