Clinicopathological spectrum of Epstein-Barr virus-associated T cell malignancies.
Clinicopathological spectrum of Epstein-Barr virus-associated T cell malignancies.
复制标题
Epstein-Barr 病毒相关 T 细胞恶性肿瘤的临床病理学谱。
作者：
I. Su;H. Hsieh
近年来研究表明，EB病毒（Epstein-Barr virus，EBV）可感染人胸腺细胞，并可能与T细胞肿瘤、非洲伯基特淋巴瘤、鼻咽癌和霍奇金病有关。四个不同的临床病理学类别的EBV相关的T细胞恶性肿瘤已被确认。累及鼻（或中线致死性肉芽肿）和皮肤的血管中心性T细胞淋巴瘤或淋巴瘤样肉芽肿病通常与EBV相关。其他3组包括血管免疫母细胞性淋巴结病样淋巴瘤、可能含有Reed-Sternberg样巨细胞的淋巴结T免疫母细胞性淋巴瘤（霍奇金样淋巴瘤）和类似恶性组织细胞增多症的T细胞淋巴瘤。涉及CD 4和CD 8 T细胞亚群以及迄今未定义的缺乏CD 4/CD 8表达的T细胞谱系。常见的临床特征是长期发热、皮肤损害、淋巴结肿大、肝脾肿大和全血细胞减少。血清学检测表明，慢性活动性EBV感染可能存在于大多数这些患者。EBV基因组在肿瘤细胞中以克隆和附加体形式增殖，表现出潜在膜蛋白的表达。虽然可能存在无痛局部期，但大多数患者的临床过程是积极的，经常出现对常规化疗的耐药性。EB病毒相关性T细胞淋巴瘤是病毒相关性疾病的一个独立实体，为研究EB病毒相关性人类恶性肿瘤的发病机制开辟了一个潜在的领域。
It has been recently demonstrated that the Epstein-Barr virus (EBV) can infect human thymocytes and may be involved in the T cell neoplasms, in addition to African Burkitt's lymphoma, nasopharyngeal carcinoma and Hodgkin's disease. Four distinct clinicopathologic categories of EBV-associated T cell malignancies have been recognized. The angiocentric T cell lymphoma or lymphomatoid granulomatosis involving the nose (or midline lethal granuloma) and skin is frequently EBV-associated. The other 3 groups include angioimmunoblastic lymphadenopathy-like lymphoma, node-based T immunoblastic lymphoma which may contain Reed-Sternberg-like giant cells (Hodgkin's-like lymphoma), and T cell lymphoma resembling malignant histiocytosis. Both the CD4 and CD8 T cell subsets, and a hitherto undefined T lineage lacking CD4/CD8 expression have been involved. The common clinical features are prolonged fever, skin lesions, lymphadenopathy, hepatosplenomegaly, and pancytopenia. Serologic assays suggest that a chronic active EBV infection may exist in most of these patients. The EBV genomes appear to proliferate in clonal and episomal form in the neoplastic cells which show expression of latent membrane proteins. Although an indolent local phase may exist, the clinical course is aggressive for most patients with frequent development of drug resistance to conventional chemotherapy. EBV-associated T cell lymphoma constitutes a separate entity of virus-associated human diseases and opens a potential field to investigate the pathogenesis of EBV-associated human malignancies.
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DOI：
--
发表时间：
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期刊：
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DOI：
--
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影响因子：
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作者：
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