Association of human leukocyte antigen class I polymorphism with spontaneous clearance of hepatitis B surface antigen in Qidong Han population.
Association of human leukocyte antigen class I polymorphism with spontaneous clearance of hepatitis B surface antigen in Qidong Han population.
复制标题
启东汉族白细胞抗原I类多态性与乙型肝炎表面抗原自发清除的关系
DOI：
10.1155/2013/145725
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发表时间：
2013
影响因子：
--
通讯作者：
Zhang J
中科院分区：
文献类型：
--
作者：
Miao F;Sun H;Pan N;Xu J;Qiu J;Shen Y;Xie W;Zhang J
瞄准探讨启东地区汉族人群中HLA I类基因多态性对B表面抗原（HBsAg）清除的影响。方法.我们通过聚合酶链反应和基于测序的分型（PCR/SBT）对448名HBV持续感染者和140名HBsAg自发清除者的HLA-A、-B和-C基因座进行了基因分型。所有受试者均为启东汉族无血缘关系的男性，随访10年。结果HBV持续感染组HLA-A等位基因频率增高（P值为0.028），HBsAg清除组HLA-B等位基因频率增高（P值为0.0004）。结论提示宿主HLA I类基因多态性是决定HBV感染转归的重要因素。
Aim. To investigate whether HLA class I polymorphisms could influence the clearance of hepatitis B surface antigen (HBsAg) in Qidong Han population. Methods. We genotyped HLA-A, -B, and -C loci of 448 individuals with HBV persistent infection and 140 persons with spontaneous clearance of HBsAg by polymerase chain reaction with sequencing based typing (PCR/SBT). All the individuals were unrelated males enrolled from Qidong Han population and were followed up for 10 years. Results. The frequency of HLA-A∗33:03:01G was increased in persistent HBV infection group (P value is 0.028), while frequency of HLA-B∗13:01:01G was increased in HBsAg clearance group (P value is 0.0004). Conclusion. These findings suggested that the host HLA class I polymorphism is an important factor in determining the outcomes of HBV infection.
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影响因子：
30.8
作者：
Martin, MP;Gao, XJ;Carrington, M
通讯作者：
Carrington, M
影响因子：
30.8
作者：
Martin, Maureen P.;Qi, Ying;Carrington, Mary
通讯作者：
Carrington, Mary
影响因子：
5.4
作者：
Thio, CL;Thomas, DL;Carrington, M
通讯作者：
Carrington, M
影响因子：
30.5
作者：
Moser, JM;Gibbs, J;Lukacher, AE
通讯作者：
Lukacher, AE
影响因子：
2.4
作者：
Albayrak, Ayse;Ertek, Mustafa;Pirim, Ibrahim
通讯作者：
Pirim, Ibrahim