Small RNAs: a new frontier in mosquito biology.

Small RNAs: a new frontier in mosquito biology.
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DOI:
10.1016/j.pt.2013.04.003
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发表时间:
2013-06
影响因子:
9.6
通讯作者:
Raikhel AS
Raikhel AS
中科院分区:
医学1区
文献类型:
--
作者:
Lucas KJ;Myles KM;Raikhel AS

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小分子非编码RNA的发现彻底改变了我们对调控动植物多种功能的调控网络的理解。然而,我们对蚊子小RNA的了解是有限的。我们在这里讨论了小RNA及其靶标在蚊子中的作用的现有知识状况,并描述了正在进行的了解RNA干扰(Randi)途径在蚊子抗病毒免疫和转座子沉默中的作用的努力。清楚地了解小RNA在蚊子媒介中的作用,将为利用这些小分子开发针对蚊子免疫和/或繁殖事件的新控制方法铺平道路。阐明小RNA的功能代表了蚊子生物学的一个新前沿。
The discovery of small non-coding RNAs has revolutionized our understanding of regulatory networks governing multiple functions in animals and plants. However, our knowledge of mosquito small RNAs are limited. We discuss here the state of current knowledge regarding the roles of small RNAs and their targets in mosquitoes, and describe the ongoing efforts to understand the role of the RNA interference (Randi) pathway in mosquito antiviral immunity and transposon silencing. Providing a clear picture into the role of small RNAs in mosquito vectors will pave the way to the utilization of these small molecules in developing novel control approaches that target mosquito immunity and/or reproductive events. Elucidation of the functions of small RNAs represents a new frontier in mosquito biology.
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