Polydatin alleviated radiation-induced lung injury through activation of Sirt3 and inhibition of epithelial-mesenchymal transition.
Polydatin alleviated radiation-induced lung injury through activation of Sirt3 and inhibition of epithelial-mesenchymal transition.
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虎杖甙通过激活 Sirt3 和抑制上皮-间质转化减轻辐射引起的肺损伤
DOI：
10.1111/jcmm.13230
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发表时间：
2017-12
影响因子：
5.3
通讯作者：
Yang Y
中科院分区：
文献类型：
--
作者：
Cao K;Lei X;Liu H;Zhao H;Guo J;Chen Y;Xu Y;Cheng Y;Liu C;Cui J;Li B;Cai J;Gao F;Yang Y
放射性肺损伤（RILI）是胸部放疗最常见和致命的并发症之一。其主要特点是早期放射性肺炎和晚期纤维化。本研究旨在研究虎杖苷（PD）的潜在辐射防护作用，PD在其他疾病中表现出抗炎和抗氧化能力。在这项研究中，我们证明了PD减轻了辐射引起的急性炎症和晚期纤维化。PD治疗抑制TGF-β1-Smad 3信号通路和上皮-间充质转化。此外，PD治疗也缓解了辐射诱导的Th 1/Th 2失衡。除了其清除自由基的能力，PD诱导培养细胞和肺组织中Sirt 3的大量增加。肺组织中Nrf 2和PGC 1 α水平也升高。总之，我们的数据表明，PD通过抑制上皮-间充质转化和增加Sirt 3的表达来减轻辐射诱导的肺损伤，这表明PD是RILI的一种新的潜在辐射保护剂。
Radiation‐induced lung injury (RILI) is one of the most common and fatal complications of thoracic radiotherapy. It is characterized with two main features including early radiation pneumonitis and fibrosis in later phase. This study was to investigate the potential radioprotective effects of polydatin (PD), which was shown to exert anti‐inflammation and anti‐oxidative capacities in other diseases. In this study, we demonstrated that PD‐mitigated acute inflammation and late fibrosis caused by irradiation. PD treatment inhibited TGF‐β1‐Smad3 signalling pathway and epithelial–mesenchymal transition. Moreover, radiation‐induced imbalance of Th1/Th2 was also alleviated by PD treatment. Besides its free radical scavenging capacity, PD induced a huge increase of Sirt3 in culture cells and lung tissues. The level of Nrf2 and PGC1α in lung tissues was also elevated. In conclusion, our data showed that PD attenuated radiation‐induced lung injury through inhibiting epithelial–mesenchymal transition and increased the expression of Sirt3, suggesting PD as a novel potential radioprotector for RILI.
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影响因子：
3.9
作者：
Han S;Gu F;Lin G;Sun X;Wang Y;Wang Z;Lin Q;Weng D;Xu Y;Mao W
通讯作者：
Mao W
影响因子：
4.3
作者：
Gremy, Olivier;Benderitter, Marc;Linard, Christine
通讯作者：
Linard, Christine
DOI：
10.1073/pnas.1407074111
发表时间：
2014-09-09
影响因子：
11.1
作者：
Risolino, Maurizio;Mandia, Nadia;Verde, Pasquale
通讯作者：
Verde, Pasquale
虎杖甙后处理可通过促进自噬通量减轻心肌缺血/再灌注损伤。
影响因子：
6
作者：
Ling, Yuanna;Chen, Guiming;Chen, Aihua
通讯作者：
Chen, Aihua
影响因子：
4.3
作者：
Park, Hae-Ran;Jo, Sung-Kee
通讯作者：
Jo, Sung-Kee