Practical considerations for choosing a mouse model of Alzheimer's disease.
Practical considerations for choosing a mouse model of Alzheimer's disease.
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DOI：
10.1186/s13024-017-0231-7
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发表时间：
2017-12-22
影响因子：
15.1
通讯作者：
Zheng H
中科院分区：
文献类型：
--
作者：
Jankowsky JL;Zheng H
阿尔茨海默病（AD）的行为特征是进行性记忆障碍，病理特征是β-淀粉样蛋白斑块、神经原纤维缠结和神经变性。基因突变和危险因素已被确定为导致或改变疾病进展的因素。这些遗传和病理特征为AD小鼠模型的建立和验证提供了基础。在过去的四分之一个世纪里，已经产生了100多个基因工程小鼠系，这些系概括了阿尔茨海默病的某些临床病理。这些模型对于理解导致疾病的遗传相互作用和参与反应的细胞反应是有价值的资源。在这里，我们将重点关注已被广泛使用的小鼠模型，这些模型是该领域的中坚力量，或者是最近开发的未来领头羊。而不是提供每个模型的总结，我们努力比较和对比所采用的遗传方法，并讨论各自的优点和局限性。我们提供了一个关键的变量帐户，这可能有助于不一致的发现和因素，应考虑选择一个模型和解释结果时。我们希望对当前的AD小鼠模型进行有见地的回顾，并为选择最适合手头实验问题的模型提供实用指南。
Alzheimer’s disease (AD) is behaviorally identified by progressive memory impairment and pathologically characterized by the triad of β-amyloid plaques, neurofibrillary tangles, and neurodegeneration. Genetic mutations and risk factors have been identified that are either causal or modify the disease progression. These genetic and pathological features serve as basis for the creation and validation of mouse models of AD. Efforts made in the past quarter-century have produced over 100 genetically engineered mouse lines that recapitulate some aspects of AD clinicopathology. These models have been valuable resources for understanding genetic interactions that contribute to disease and cellular reactions that are engaged in response. Here we focus on mouse models that have been widely used stalwarts of the field or that are recently developed bellwethers of the future. Rather than providing a summary of each model, we endeavor to compare and contrast the genetic approaches employed and to discuss their respective advantages and limitations. We offer a critical account of the variables which may contribute to inconsistent findings and the factors that should be considered when choosing a model and interpreting the results. We hope to present an insightful review of current AD mouse models and to provide a practical guide for selecting models best matched to the experimental question at hand.
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影响因子：
16.2
作者：
Bhaskar, Kiran;Konerth, Megan;Kokiko-Cochran, Olga N.;Cardona, Astrid;Ransohoff, Richard M.;Lamb, Bruce T.
通讯作者：
Lamb, Bruce T.
影响因子：
5.3
作者：
Bondolfi, L;Calhoun, M;Jucker, M
通讯作者：
Jucker, M
影响因子：
4.2
作者：
Malthankar-Phatak G;Poplawski S;Toraskar N;Siman R
通讯作者：
Siman R
影响因子：
6
作者：
Callahan, MJ;Lipinski, WJ;Walker, LC
通讯作者：
Walker, LC
影响因子：
5.3
作者：
Born, Heather A.;Kim, Ji-Yoen;Jankowsky, Joanna L.
通讯作者：
Jankowsky, Joanna L.