PTGFR and SLCO2A1 Gene Polymorphisms Determine Intraocular Pressure Response to Latanoprost in Han Chinese Patients with Glaucoma
PTGFR and SLCO2A1 Gene Polymorphisms Determine Intraocular Pressure Response to Latanoprost in Han Chinese Patients with Glaucoma
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PTGFR 和 SLCO2A1 基因多态性决定中国汉族青光眼患者对拉坦前列素的眼压反应
DOI：
10.3109/02713683.2016.1143013
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发表时间：
2016-06
影响因子：
2
通讯作者：
Huang Wei
中科院分区：
文献类型：
--
作者：
Zhang Pu;Jiang Bing;Xie Lili;Huang Wei
目的：探讨中国汉族青光眼患者前列腺素F2α受体（PTGFR）和溶质载体有机阴离子转运蛋白家族2A 1（SLCO 2A 1）基因多态性与拉坦前列素治疗反应的关系。使用直接DNA测序或聚合酶链反应-限制性片段长度多态性分析PTGFR基因中的rs 12093097、rs35586449、rs3753380和rs3766355单核苷酸多态性（SNP）以及SLCO 2A 1基因中的rs 2370512、rs34550074和rs 4241366 SNP结果：rs 4241366 GG等位基因携带者的眼压在第7天低于GC+CC患者（p = 0.007）。在第30天，具有rs3766355的CC等位基因的患者的IOP低于具有CA+AA的患者（p = 0.024）。多元回归分析表明，即使在调整基线IOP后，SLCO 2A 1基因中的rs 4241366和PTGFR基因中的rs3766355也与第7天对拉坦前列素的反应相关（rs 4241366，p = 0.014）和第30天（rs3766355，p = 0.035）。在中国汉族青光眼患者中，PTGFR和SLCO 2A 1基因的单核苷酸多态性与拉坦前列素的疗效相关。这些SNPs可能是拉坦前列素不同应答的重要决定因素。
Purpose:To determine the relationship between the polymorphisms of the prostaglandin F2α receptor (PTGFR) and solute carrier organic anion transporter family 2A1 (SLCO2A1) genes and response to latanoprost treatment in Han Chinese patients with glaucoma.Materials and methods:89 patients with POAG or OH received latanoprost treatment and intraocular pressure (IOP) data was collected on day 7 and day 30. The rs12093097, rs35586449, rs3753380, and rs3766355 single-nucleotide polymorphisms (SNPs) in the PTGFR gene and rs2370512, rs34550074, and rs4241366 SNPs in the SLCO2A1 gene were analyzed using direct DNA sequencing or polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).Results:The IOP in patients with GG allele of rs4241366 was lower than in patients with GC+CC on day 7 (p = 0.007). The IOP in patients with CC allele of rs3766355 was lower than in patients with CA+AA on day 30 (p = 0.024). Multiple regression analysis demonstrated that even after adjusting for baseline IOP, the rs4241366 in SLCO2A1 gene and the rs3766355 in PTGFR gene correlated with response to latanoprost on day 7 (rs4241366, p = 0.014) and day 30 (rs3766355, p = 0.035), respectively, in Han Chinese patients with glaucoma.Conclusions:An association was found between single nucleotide polymorphisms of the PTGFR and SLCO2A1 genes and the response to latanoprost in Han Chinese patients with glaucoma. These SNPs may be important determinants of differential response to latanoprost.
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影响因子：
4.4
作者：
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通讯作者：
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影响因子：
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作者：
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影响因子：
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通讯作者：
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