Effect of maternal n-3 long-chain polyunsaturated fatty acid supplementation during pregnancy and/or lactation on adiposity in childhood: a systematic review and meta-analysis of randomized controlled trials
Effect of maternal n-3 long-chain polyunsaturated fatty acid supplementation during pregnancy and/or lactation on adiposity in childhood: a systematic review and meta-analysis of randomized controlled trials
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怀孕和/或哺乳期母亲补充 n-3 长链多不饱和脂肪酸对儿童肥胖的影响：随机对照试验的系统评价和荟萃分析
DOI：
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发表时间：
2014
影响因子：
4.7
通讯作者：
M. Zeegers
中科院分区：
文献类型：
--
作者：
Nikos Stratakis;Nikos Stratakis;M. Gielen;L. Chatzi;M. Zeegers
It is hypothesized that prenatal and early postnatal exposure to n-3 long-chain polyunsaturated fatty acids (LCPUFAs) is negatively associated with adiposity later in life. We conducted a systematic review and meta-analysis to evaluate whether maternal n-3 LCPUFA supplementation in pregnancy and/or lactation exerts a beneficial effect on adiposity status in childhood. We searched six electronic databases till 20 May 2014 for randomized controlled trials (RCTs) of n-3 LCPUFA supplementation to pregnant and/or lactating women that reported data on body mass index (BMI), waist circumference, sum of skinfold thicknesses or body fat mass in children. Adiposity measures were grouped into three age categories: preschool children (<5 years), school-aged children (6–12 years), and adolescents (>13 years). Trial quality was assessed. We conducted fixed-effect and random-effects meta-analyses to combine study-specific estimates of differences between the supplemented and control groups. A total of 6 RCTs (9 publications) involving 2847 participants were included. Summary estimates showed no effect of maternal supplementation on BMI in preschool (standardized mean difference (SMD)=0.07, 95% confidence interval (CI)=−0.22, 0.36, P=0.65) and school-aged children (SMD=0.12, 95% CI=−0.06, 0.30, P=0.20). Because of sparse data, it was not possible to pool study results relating to other adiposity measures. There is currently no evidence to support that n-3 LCPUFA supplementation during pregnancy and/or lactation favourably affects child adiposity. Further high-quality trials are needed.
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怀孕期间鱼油的摄入量和 19 岁后代的肥胖：随机对照试验的随访。
DOI：
10.3945/ajcn.111.014969
发表时间：
2011
期刊：
The American journal of clinical nutrition
影响因子：
--
作者：
Rytter,Dorte;Bech,BodilH;Christensen,JeppeH;Schmidt,ErikB;Henriksen,TineB;Olsen,SjurdurF
通讯作者：
Olsen,SjurdurF
影响因子：
3.7
作者：
Schellong K;Schulz S;Harder T;Plagemann A
通讯作者：
Plagemann A
在墨西哥，产前补充二十二碳六烯酸后生长至 18 个月的年龄因母亲妊娠情况而异。
DOI：
10.3945/jn.110.128215
发表时间：
2011
期刊：
The Journal of nutrition
影响因子：
--
作者：
Stein,AryehD;Wang,Meng;Martorell,Reynaldo;Neufeld,LynnetteM;Flores-Ayala,Rafael;Rivera,JuanA;Ramakrishnan,Usha
通讯作者：
Ramakrishnan,Usha
影响因子：
7.1
作者：
Donahue, Sara M. A.;Rifas-Shiman, Sheryl L.;Oken, Emily
通讯作者：
Oken, Emily