Regulation of myeloid-cell activation.
Regulation of myeloid-cell activation.
复制标题
DOI：
10.1016/j.coi.2021.09.004
复制
发表时间：
2021-12
影响因子：
7
通讯作者：
Freedman TS
中科院分区：
文献类型：
--
作者：
Greene JT;Brian BF 4th;Senevirathne SE;Freedman TS
髓样细胞（巨噬细胞、单核细胞、树突细胞和粒细胞）检查身体是否有感染和组织损伤的迹象，并调节组织稳态、器官发生和免疫力。它们表达引发炎症反应的受体，发送改变血管和细胞因子环境的信号，并监督其他骨髓和适应性免疫细胞的招募，分化和激活。因此，它们的激活必须受到严格的调控，优化以获得最大的先天免疫保护，同时将附带组织损伤或组织解体降至最低。在这篇综述中，我们讨论了髓系细胞被激活意味着什么，重点是对识别病原体和损伤相关分子模式至关重要的受体和信号分子。我们还概述了这些信号是如何通过蛋白质的空间特性、粘附和细胞骨架相互作用以及负反馈来调节的，以保持炎症的控制并支持健康的组织发育和体内平衡。在整个文本中，我们强调了最近的出版物和评论，说明了骨髓细胞调节的关键要素，并直接读者在其中的综合书目。髓样细胞（巨噬细胞、单核细胞、树突细胞和粒细胞）检查组织是否存在感染和损伤的迹象，并调节组织稳态、器官发生和免疫。它们表达引发炎症反应的受体，改变血管和细胞因子环境，并监督其他骨髓和适应性免疫细胞的招募，分化和活化。因此，它们的激活必须受到严格的调控，优化以最大限度地保护最小的附带组织损伤。在这里，我们讨论了髓系细胞被激活的意义，重点是识别病原体和损伤相关分子模式的受体和信号分子。我们概述了这些信号是如何通过蛋白质的空间特性，粘附和细胞骨架相互作用以及负反馈来调节的，以保持炎症的检查并支持健康的组织发育和体内平衡。在整个文本中，我们强调了最近的出版物和评论，说明了骨髓细胞调节的关键要素，并直接读者在其中的综合书目。
Myeloid cells (macrophages, monocytes, dendritic cells, and granulocytes) survey the body for signs of infection and tissue damage and regulate tissue homeostasis, organogenesis, and immunity. They express receptors that initiate the inflammatory response, send signals that alter the vascular and cytokine milieu, and oversee the recruitment, differentiation, and activation of other myeloid and adaptive immune cells. Their activation must therefore be tightly regulated, optimized for maximal innate-immune protection with a minimum of collateral tissue damage or disorganization. In this review we discuss what it means for myeloid cells to become activated, with emphasis on the receptors and signaling molecules important for the recognition of pathogen- and damage-associated molecular patterns. We also outline how these signals are regulated by the steric properties of proteins, by adhesive and cytoskeletal interactions, and by negative feedback to keep inflammation in check and support healthy tissue development and homeostasis. Throughout the text we highlight recent publications and reviews that illustrate key elements of myeloid-cell regulation and direct readers therein for a comprehensive bibliography. Myeloid cells (macrophages, monocytes, dendritic cells, and granulocytes) survey tissues for signs of infection and damage and regulate tissue homeostasis, organogenesis, and immunity. They express receptors that initiate the inflammatory response, alter the vascular and cytokine milieu, and oversee the recruitment, differentiation, and activation of other myeloid and adaptive immune cells. Their activation must therefore be tightly regulated, optimized for maximal protection with minimum collateral tissue damage. Here we discuss what it means for myeloid cells to become activated, with emphasis on receptors and signaling molecules recognizing pathogen- and damage-associated molecular patterns. We outline how these signals are regulated by steric properties of proteins, adhesive and cytoskeletal interactions, and negative feedback to keep inflammation in check and support healthy tissue development and homeostasis. Throughout the text we highlight recent publications and reviews that illustrate key elements of myeloid-cell regulation and direct readers therein for a comprehensive bibliography.
登录
查看更多内容
影响因子：
64.5
作者：
Freeman SA;Vega A;Riedl M;Collins RF;Ostrowski PP;Woods EC;Bertozzi CR;Tammi MI;Lidke DS;Johnson P;Mayor S;Jaqaman K;Grinstein S
通讯作者：
Grinstein S
影响因子：
7.7
作者：
Cunin, Pierre;Bouslama, Rim;Nigrovic, Peter A.
通讯作者：
Nigrovic, Peter A.
影响因子：
32.4
作者：
Andrews, Nicholas L.;Pfeiffer, Janet R.;Lidke, Diane S.
通讯作者：
Lidke, Diane S.
影响因子：
30.5
作者：
Aegerter, Helena;Kulikauskaite, Justina;Wack, Andreas
通讯作者：
Wack, Andreas
大小依赖性分离控制巨噬细胞对抗体调理靶标的吞噬作用。
影响因子：
64.5
作者：
Bakalar MH;Joffe AM;Schmid EM;Son S;Podolski M;Fletcher DA
通讯作者：
Fletcher DA