Regulation of sex hormone receptors in sexual dimorphism of human cancers.

Regulation of sex hormone receptors in sexual dimorphism of human cancers.
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DOI:
10.1016/j.canlet.2018.09.001
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发表时间:
2018-12-01
期刊:
影响因子:
9.7
通讯作者:
Li Z
Li Z
中科院分区:
医学1区
文献类型:
--
作者:
Zheng D;Williams C;Vold JA;Nguyen JH;Harnois DM;Bagaria SP;McLaughlin SA;Li Z

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几乎在所有人类癌症中都发现了癌症发病率的性别差异。然而,大多数人类癌症类型中性别差异的机制尚未得到充分研究。在这里,我们提供了一个全面的概述潜在的机制,每种癌症的性二态性有关性激素信号。充分解决人类癌症中性别二态性的机制将极大地有利于当前精准医学的发展。我们对每种癌症中性别二型性潜在机制的讨论将对未来关于性别差异的癌症研究具有指导意义。
Gender differences in the incidences of cancers have been found in almost all human cancers. However, the mechanisms that underlie gender disparities in most human cancer types have been under-investigated. Here, we provide a comprehensive overview of potential mechanisms underlying sexual dimorphism of each cancer regarding sex hormone signaling. Fully addressing the mechanisms of sexual dimorphism in human cancers will greatly benefit current development of precision medicine. Our discussions of potential mechanisms underlying sexual dimorphism in each cancer will be instructive for future cancer research on gender disparities.
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