Epidemiology and risk factors for kidney cancer.
Epidemiology and risk factors for kidney cancer.
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DOI：
10.1038/nrurol.2010.46
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发表时间：
2010-05
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影响因子：
--
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经过二十多年的增长率，近年来全球肾癌发病率趋势显示出平稳或下降的迹象。在美国，肾细胞癌（成人肾癌的主要形式）的发病率继续上升，但主要是早期肿瘤。肾盂癌的发病率有所下降，而肾癌的死亡率总体上保持不变。这些模式与临床系列中偶然诊断和肿瘤分期和大小下移的报告一致。已知的肾细胞癌危险因素（包括吸烟、肥胖和高血压）的患病率变化也可能影响发病率趋势，尽管其相对影响在不同人群中可能不同。越来越多的证据表明，体力活动、饮酒、职业接触三氯乙烯以及女性的高生育率都是病因，但因果结论尚未得到支持。遗传易感性及其与环境暴露的相互作用被认为会影响肾细胞癌的风险，但基于候选基因方法的有限研究尚未产生结论性结果。采用全基因组扫描技术的大型联盟正在进行中，这有望在肾癌发生中获得新的发现。
After over two decades of increasing rates, kidney cancer incidence trends worldwide show signs of plateauing or decreases in recent years. In the United States, rates for renal cell cancer, the predominant form of kidney cancer in adults, continue to rise but mainly for early stage tumors. Incidence rates for renal pelvis cancer have declined, while kidney cancer mortality rates overall have leveled. These patterns are consistent with reports of incidental diagnosis and downward shift of tumor stage and size in clinical series. The changing prevalence of known risk factors for renal cell cancer, including cigarette smoking, obesity, and hypertension, may also be influencing the incidence trends, although their relative impact may differ in various populations,. Evidence is accumulating to suggest an etiologic role for physical activity, alcohol consumption, occupational exposure to trichloroethylene, and high parity among women, but causal conclusions are not yet supported. Genetic susceptibility and its interaction with environmental exposures are believed to influence renal cell cancer risk, but limited studies based on candidate gene approaches have not produced conclusive results. Large consortium efforts employing genome-wide scanning technology are underway, which hold promise for novel discoveries in renal carcinogenesis.
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DOI：
10.1186/1745-6673-2-13
发表时间：
2007-11-12
期刊：
Journal of occupational medicine and toxicology (London, England)
影响因子：
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作者：
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Richard, Stephane
影响因子：
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DOI：
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发表时间：
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期刊：
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影响因子：
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影响因子：
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