Middle-age high normal serum sodium as a risk factor for accelerated biological aging, chronic diseases, and premature mortality.
Middle-age high normal serum sodium as a risk factor for accelerated biological aging, chronic diseases, and premature mortality.
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DOI：
10.1016/j.ebiom.2022.104404
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发表时间：
2023-01
期刊：
影响因子：
11.1
通讯作者：
Boehm, Manfred
中科院分区：
文献类型：
--
作者：
Dmitrieva, Natalia I.;Gagarin, Alessandro;Liu, Delong;Wu, Colin O.;Boehm, Manfred
It is known that some people age faster than others, some people live into old age disease-free, while others develop age-related chronic diseases. With a rapidly aging population and an emerging chronic diseases epidemic, finding mechanisms and implementing preventive measures that could slow down the aging process has become a new challenge for biomedical research and public health. In mice, lifelong water restriction shortens the lifespan and promotes degenerative changes. Here, we test the hypothesis that optimal hydration may slow down the aging process in humans. We performed a cohort analysis of data from the Atherosclerosis Risk in Communities study with middle-age enrollment (45–66 years, n = 15,752) and 25 years follow-up. We used serum sodium, as a proxy for hydration habits. To estimate the relative speed of aging, we calculated the biological age (BA) from age-dependent biomarkers and assessed risks of chronic diseases and premature mortality. The analysis showed that middle age serum sodium >142 mmol/l is associated with a 39% increased risk to develop chronic diseases (hazard ratio [HR] = 1.39, 95% confidence interval [CI]:1.18–1.63) and >144 mmol/l with 21% elevated risk of premature mortality (HR = 1.21, 95% CI:1.02–1.45). People with serum sodium >142 mmol/l had up to 50% higher odds to be older than their chronological age (OR = 1.50, 95% CI:1.14–1.96). A higher BA was associated with an increased risk of chronic diseases (HR = 1.70, 95% CI:1.50–1.93) and premature mortality (HR = 1.59, 95% CI 1.39–1.83). People whose middle-age serum sodium exceeds 142 mmol/l have increased risk to be biologically older, develop chronic diseases and die at younger age. Intervention studies are needed to confirm the link between hydration and aging. This work was funded by Intramural Research program of the (NHLBI). The ARIC study has been funded in whole or in part with federal funds from the NHLBI; the (NIH); and the .
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影响因子：
64.5
作者：
de Cabo R;Carmona-Gutierrez D;Bernier M;Hall MN;Madeo F
通讯作者：
Madeo F
影响因子：
20.8
作者：
BRESLOW, N
通讯作者：
BRESLOW, N
DOI：
10.1038/s41569-018-0064-2
发表时间：
2018-09
期刊：
Nature reviews. Cardiology
影响因子：
--
作者：
Ferrucci L;Fabbri E
通讯作者：
Fabbri E
影响因子：
3.7
作者：
Dmitrieva NI;Burg MB
通讯作者：
Burg MB
DOI：
10.1093/gerona/glx096
发表时间：
2018-01-01
影响因子：
5.1
作者：
Belsky, Daniel W.;Huffman, Kim M.;Kraus, William E.
通讯作者：
Kraus, William E.