Pulmonary endpoints (lung carcinomas and asbestosis) following inhalation exposure to asbestos.
Pulmonary endpoints (lung carcinomas and asbestosis) following inhalation exposure to asbestos.
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DOI：
10.1080/10937404.2011.556047
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Bonner JC
中科院分区：
文献类型：
--
作者：
Mossman BT;Lippmann M;Hesterberg TW;Kelsey KT;Barchowsky A;Bonner JC
石棉工人可患肺癌和肺纤维化（石棉肺）。了解这些疾病的发病机制是复杂的，因为潜在的混杂因素，如吸烟，这不是间皮瘤的一个危险因素。不同类型石棉在肺癌、石棉肺和间皮瘤发展中的作用模式（MOA）似乎是不同的。此外，与其他天然纤维和合成纤维相比，石棉纤维在这些疾病的不同阶段可能表现不同，并且具有不同的效力。这篇文献综述描述了各种类型的石棉和其他纤维在吸入后的沉积和滞留模式，肺内易位的方法，以及各种类型的纤维在体外肺室和细胞中的溶解。在已发表的研究中，很少对人体吸入纤维浓度以及纤维的双变量尺寸分布（长度和宽度）、类型和来源进行全面的剂量-反应研究，这是必要的。可能会发生物种特异性反应。机制研究有一些局限性，但已经表明基因表达的变化（纤维直接催化或通过细胞氧化作用）、表观遗传变化、受体介导或其他细胞内信号级联反应可能在肺癌或石棉肺发展的各个阶段发挥作用。
Lung carcinomas and pulmonary fibrosis (asbestosis) occur in asbestos workers. Understanding the pathogenesis of these diseases is complicated because of potential confounding factors, such as smoking, which is not a risk factor in mesothelioma. The modes of action (MOA) of various types of asbestos in the development of lung cancers, asbestosis, and mesotheliomas appear to be different. Moreover, asbestos fibers may act differentially at various stages of these diseases, and have different potencies as compared to other naturally occurring and synthetic fibers. This literature review describes patterns of deposition and retention of various types of asbestos and other fibers after inhalation, methods of translocation within the lung, and dissolution of various fiber types in lung compartments and cells in vitro. Comprehensive dose-response studies at fiber concentrations inhaled by humans as well as bivariate size distributions (lengths and widths), types, and sources of fibers are rarely defined in published studies and are needed. Species-specific responses may occur. Mechanistic studies have some of these limitations, but have suggested that changes in gene expression (either fiber-catalyzed directly or by cell elaboration of oxidants), epigenetic changes, and receptor-mediated or other intracellular signaling cascades may play roles in various stages of the development of lung cancers or asbestosis.
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影响因子：
2.1
作者：
Bernstein, DM;Rogers, R;Smith, P
通讯作者：
Smith, P
影响因子：
3.8
作者：
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3.8
作者：
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2.1
作者：
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2.1
作者：
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