Sense and Immunity: Context-Dependent Neuro-Immune Interplay.
Sense and Immunity: Context-Dependent Neuro-Immune Interplay.
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DOI：
10.3389/fimmu.2017.01463
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发表时间：
2017
影响因子：
7.3
通讯作者：
Talbot S
中科院分区：
文献类型：
--
作者：
Foster SL;Seehus CR;Woolf CJ;Talbot S
感觉神经和免疫系统，历史上被认为是自主的，实际上是协同工作，以促进宿主防御和组织稳态。这些系统通过细胞表面G蛋白偶联受体和受体酪氨酸激酶以及细胞因子、生长因子和神经肽的共同语言相互作用。虽然这种双向交流在许多情况下是适应性的，有助于保护免受危险，但它也可能变得适应不良并导致疾病病理生理学。然而，感觉神经元和免疫细胞如何、在何处以及何时对健康或疾病做出贡献的基本逻辑仍然不清楚。我们的实验室和其他实验室已经开始探索这种神经免疫相互对话如何有助于生理和病理免疫反应和感觉障碍。迄今为止收集的累积结果表明，伤害感受器（检测感觉神经元的有害刺激）在驱动免疫反应中起着重要作用，但这是高度依赖于上下文的。为了说明这一概念，我们在气道炎症模型中提出了我们的发现，其中伤害感受器似乎主要参与2型而不是1型适应性免疫。
The sensory nervous and immune systems, historically considered autonomous, actually work in concert to promote host defense and tissue homeostasis. These systems interact with each other through a common language of cell surface G protein-coupled receptors and receptor tyrosine kinases as well as cytokines, growth factors, and neuropeptides. While this bidirectional communication is adaptive in many settings, helping protect from danger, it can also become maladaptive and contribute to disease pathophysiology. The fundamental logic of how, where, and when sensory neurons and immune cells contribute to either health or disease remains, however, unclear. Our lab and others’ have begun to explore how this neuro-immune reciprocal dialog contributes to physiological and pathological immune responses and sensory disorders. The cumulative results collected so far indicate that there is an important role for nociceptors (noxious stimulus detecting sensory neurons) in driving immune responses, but that this is highly context dependent. To illustrate this concept, we present our findings in a model of airway inflammation, in which nociceptors seem to have major involvement in type 2 but not type 1 adaptive immunity.
DOI：
10.4168/aair.2012.4.2.104
发表时间：
2012-03
期刊：
Allergy, asthma & immunology research
影响因子：
--
作者：
Nam YH;Jin HJ;Hwang EK;Shin YS;Ye YM;Park HS
通讯作者：
Park HS