Role of host genetic factors in the outcome of hepatitis C virus infection.
Role of host genetic factors in the outcome of hepatitis C virus infection.
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DOI：
10.3390/v1020104
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发表时间：
2009-09
期刊：
影响因子：
--
通讯作者：
Blum HE
中科院分区：
文献类型：
--
作者：
Bengsch B;Thimme R;Blum HE
丙型肝炎病毒（HCV）感染的自然史是由宿主遗传、免疫和病毒因素之间复杂的相互作用决定的。这篇综述强调了先天性和适应性免疫反应与HCV感染的不同结果相关的基因。例如，已证实HCV清除与某些HLA等位基因的关联。负责这些关联的机制已经与某些特定等位基因的特异性T细胞应答（例如，HLA-B27）。参与T细胞调节和功能的遗传关联进一步强调了适应性免疫应答在HCV感染自然史中的作用。此外，参与先天性NK细胞应答的一些基因证明了宿主对HCV感染的成功应答所必需的免疫系统组分之间的复杂相互作用。
The natural history of hepatitis C virus (HCV) infection is determined by a complex interplay between host genetic, immunological and viral factors. This review highlights genes involved in innate and adaptive immune responses associated with different outcomes of HCV infection. For example, an association of HCV clearance with certain HLA alleles has been demonstrated. The mechanisms responsible for these associations have been linked to specific T cell responses for some particular alleles (e.g., HLA-B27). Genetic associations involved in T cell regulation and function further underline the role of the adaptive immune response in the natural history of HCV infection. In addition, some genes involved in innate NK cell responses demonstrate the complex interplay between components of the immune system necessary for a successful host response to HCV infection.
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