Total Antioxidant Status Correlates with Cognitive Impairment in Patients with Recurrent Depressive Disorder
Total Antioxidant Status Correlates with Cognitive Impairment in Patients with Recurrent Depressive Disorder
复制标题
总抗氧化状态与复发性抑郁症患者的认知障碍相关
DOI：
10.1007/s11064-012-0788-z
复制
发表时间：
2012
影响因子：
4.4
通讯作者：
E. Kowalczyk
中科院分区：
文献类型：
--
作者：
M. Talarowska;P. Gałecki;M. Maes;K. Bobińska;E. Kowalczyk
抑郁症是一种多因素疾病，其典型特征之一是认知障碍。本研究的目的是确定复发性抑郁症（rDD）患者的总抗氧化状态（TAS），并确定TAS的血浆水平与认知能力之间的关系。设计和方法：本研究包括74名受试者：rDD患者（n = 45）和健康受试者（n = 29）。认知功能评估的基础是：造径测验、Stroop测验、语言流畅性测验和听觉语言学习测验。治疗开始时用汉密尔顿抑郁评定量表（HDRS）测量的抑郁症状强度与治疗8周后的检查结果有统计学显著差异（p < 0.001）。rDD患者的TAS水平明显较高（p = 0.01）。对于rDD患者，TAS水平升高与认知测试表现较差相关。血浆TAS浓度越高，药物治疗前后HDRS测量的抑郁症状严重程度越高。(1) rDD患者血浆TAS浓度较高与抑郁症状的严重程度相关。(2)血浆TAS水平升高与短期陈述性记忆、长期陈述性记忆、言语流畅性和工作记忆的损害有关。
Depressive disorder is a multifactorial diseases, that one of the typical feature are cognitive impairments. The aim of this study was to determine the total antioxidant status (TAS) in patients with recurrent depressive disorder (rDD) and to define relationship between plasma levels of TAS and the cognitive performance. Design and methods: the study comprised 74 subjects: patients with rDD (n = 45) and healthy subjects (n = 29). Cognitive function assessment was based on: Trail Making Test, The Stroop Test, Verbal Fluency Test and Auditory Verbal Learning Test. Statistically significant differences were found in the intensity of depression symptoms, measured by the Hamilton Depression Rating Scale (HDRS) on therapy onset versus the examination results after 8 weeks of treatment (p < 0.001). The level of TAS was substantially higher in patients with rDD (p = 0.01). For rDD patients, elevated TAS levels were associated with worse cognitive test performance. The higher was the concentration of plasma TAS, the greater was the severity of depressive symptoms measured by HDRS before and after pharmacotherapy. (1) Higher concentration of plasma TAS in rDD patients is associated with the severity of depressive symptoms. (2) Elevated levels of plasma TAS are related to impairment of short-term declarative memory, long-term declarative-memory, verbal fluency and working memory.
影响因子：
7.4
作者：
Floyd, Robert A.;Towner, Rheal A.;He, Ting;Hensley, Kenneth;Maples, Kirk R.
通讯作者：
Maples, Kirk R.
影响因子：
2.6
作者：
Considine, Ciaran M.;Weisenbach, Sara L.;Langenecker, Scott A.
通讯作者：
Langenecker, Scott A.