Testosterone and imipramine have antidepressant effects in socially isolated male but not female rats.
Testosterone and imipramine have antidepressant effects in socially isolated male but not female rats.
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DOI：
10.1016/j.yhbeh.2012.03.001
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发表时间：
2012-05
影响因子：
3.5
通讯作者：
Kabbaj, Mohamed
中科院分区：
文献类型：
--
作者：
Carrier, Nicole;Kabbaj, Mohamed
关键词：
情感性障碍在女性中发生的可能性是男性的两倍，这表明性腺激素在其病因中起着关键作用。特别是，睾丸素已被证明对男性具有保护作用。目的：研究睾酮和丙咪嗪对社交隔离雄性和雌性大鼠的抗抑郁作用及其相互作用。采用慢性社会隔离模型，对成年去性腺(GNX)雄性和去卵巢(OVX)雌性大鼠进行慢性睾酮和丙咪嗪治疗，建立焦虑和抑郁样状态。采用明暗箱、高架迷宫、空旷场、蔗糖偏爱和新奇诱导的低噬试验检测焦虑和抑郁样行为。在与世隔绝的大鼠中，睾酮和丙咪嗪的抗焦虑和抗抑郁作用仅限于雄性大鼠。此外，睾酮增强了丙咪嗪对雄性大鼠海马细胞增殖的神经原性作用。虽然雌性大鼠在社交隔离后表现出焦虑和抑郁样行为的迹象，但在OVX雌性大鼠中，睾酮和/或丙咪嗪的注射没有缓解焦虑或抗抑郁的作用。睾酮和丙咪嗪对社交隔离的雄性大鼠有缓解焦虑和抗抑郁的作用，但对雌性大鼠没有作用。睾酮增强丙咪嗪对雄性大鼠海马区细胞增殖的影响。
Affective disorders are twice as likely to occur in women as they are in men suggesting a critical role for gonadal hormones in their etiology. In particular, testosterone has been shown to have protective effects in men. To investigate antidepressant effects and interactions between testosterone and imipramine in socially isolated male and female rats. A chronic social isolation model was used to induce an anxiety and depressive-like state in adult gonadectomized (Gnx) male and ovariectomized (Ovx) female rats receiving chronic testosterone and imipramine treatments. Their anxiety and depression-like behaviors were examined using the light-dark box, elevated plus maze, open field, sucrose preference and novelty induced hypophagia tests. In socially isolated rats, the anxiolytic and antidepressant effects of testosterone and imipramine were limited to male rats. Additionally, testosterone enhanced the neurogenic effect of imipramine on hippocampal cell proliferation in male rats. Although female rats exhibited signs of anxiety and depressive-like behaviors following social isolation, testosterone and/or imipramine administration had no anxiolytic or antidepressant effects in Ovx females. Testosterone and imipramine had anxiolytic and antidepressant effects in socially isolated male, but not female rats. Testosterone enhanced the effect of imipramine on cell proliferation in the hippocampus of male rats.
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DOI：
10.1037/h0077264
发表时间：
1976-01-01
期刊：
JOURNAL OF COMPARATIVE AND PHYSIOLOGICAL PSYCHOLOGY
影响因子：
--
作者：
GENTRY, RT;WADE, GN
通讯作者：
WADE, GN
影响因子：
2.9
作者：
Buwalda, Bauke;van der Borght, Karin;McEwen, Bruce S.
通讯作者：
McEwen, Bruce S.
影响因子：
2.9
作者：
Frye, Cheryl A.;Walf, Alicia A.
通讯作者：
Walf, Alicia A.
影响因子：
4.8
作者：
Kentner, A. C.;McLeod, S. A.;Pittman, Q. J.
通讯作者：
Pittman, Q. J.
影响因子：
3
作者：
Li, CM;Joshee, N;Cheng, PW
通讯作者：
Cheng, PW