The cells of the allergic response: mast cells, basophils, and eosinophils.

The cells of the allergic response: mast cells, basophils, and eosinophils.
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过敏反应的细胞:肥大细胞、嗜碱性粒细胞和嗜酸性粒细胞。

DOI:
10.1001/jama.1997.03550220021005
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发表时间:
1997
期刊:
JAMA
影响因子:
--
通讯作者:
S. Galli
S. Galli
中科院分区:
--
文献类型:
--
作者:
J. J. Costa;P. Weller;S. Galli

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肥大细胞、嗜碱性粒细胞和嗜酸性粒细胞一直被认为是过敏性疾病的重要效应细胞。事实上,人们认为细胞的细胞质颗粒相关介质或脂质介质促成了这些疾病的许多特征体征和症状。肥大细胞、嗜碱性粒细胞和嗜酸性粒细胞也可能参与宿主的保护性反应,尤其是对寄生虫。此外,最近的证据表明肥大细胞、嗜碱性粒细胞和嗜酸性粒细胞可以分泌广泛的细胞因子,在某些情况下,表达的功能可能允许它们调节过敏反应的发展或持续。因此,肥大细胞、嗜碱性细胞和嗜酸性细胞可以表达免疫调节活性,也可以作为效应细胞。
Mast cells, basophils, and eosinophils have long been regarded as important effector cells in allergic disorders. Indeed, it is thought that the cells' cytoplasmic granule-associated or lipid mediators contribute to many of the signs and symptoms that are characteristic of these diseases. Mast cells, basophils, and eosinophils also probably contribute to protective host responses, especially to parasites. In addition, recent evidence shows that mast cells, basophils, and eosinophils can secrete a wide spectrum of cytokines and, in some cases, express functions that may permit them to regulate the development or perpetuation of allergic responses. Thus, mast cells, basophils, and eosinophils may express immunoregulatory activities, as well as serve as effector cells.
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DOI: 10.1016/s0091-6749(95)70057-9
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