Epigenetic Regulation of Nucleotide Excision Repair.
Epigenetic Regulation of Nucleotide Excision Repair.
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DOI：
10.3389/fcell.2022.847051
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发表时间：
2022
影响因子：
5.5
通讯作者：
中科院分区：
文献类型：
--
作者：
基因组 DNA 不断受到来自内源和外源的大量 DNA 损伤剂的攻击。核苷酸切除修复 (NER) 是最通用的修复途径，可识别并去除各种大体积和/或螺旋扭曲的 DNA 损伤。尽管通过体外系统充分研究了NER的分子机制，但细胞内的NER过程更加复杂，因为真核生物中的基因组DNA被紧密包装到染色体中并压缩到细胞核中。表观遗传修饰可在不改变 DNA 序列的情况下调节基因活性和表达。表观遗传调控的动态在体内 NER 过程中发挥着至关重要的作用。在这篇综述中，我们总结了我们对 NER 表观遗传调控的理解的最新进展。
Genomic DNA is constantly attacked by a plethora of DNA damaging agents both from endogenous and exogenous sources. Nucleotide excision repair (NER) is the most versatile repair pathway that recognizes and removes a wide range of bulky and/or helix-distorting DNA lesions. Even though the molecular mechanism of NER is well studied through in vitro system, the NER process inside the cell is more complicated because the genomic DNA in eukaryotes is tightly packaged into chromosomes and compacted into a nucleus. Epigenetic modifications regulate gene activity and expression without changing the DNA sequence. The dynamics of epigenetic regulation play a crucial role during the in vivo NER process. In this review, we summarize recent advances in our understanding of the epigenetic regulation of NER.
翻译后组蛋白修饰在核苷酸切除修复中的影响。
影响因子：
5.6
作者：
Li S
通讯作者：
Li S
影响因子：
14.9
作者：
Irizar A;Yu Y;Reed SH;Louis EJ;Waters R
通讯作者：
Waters R