Implication of posttranslational histone modifications in nucleotide excision repair.
Implication of posttranslational histone modifications in nucleotide excision repair.
复制标题
翻译后组蛋白修饰在核苷酸切除修复中的影响。
DOI：
10.3390/ijms131012461
复制
发表时间：
2012-09-28
影响因子：
5.6
通讯作者：
Li S
中科院分区：
文献类型：
--
作者：
Li S
组蛋白是真核细胞中将DNA包装和排列成染色质的强碱性蛋白质。核苷酸切除修复（NER）是一种保守的多步反应，其去除广泛的通常庞大的和/或螺旋扭曲的DNA损伤。虽然NER的核心生化机制相对较为人所知，但细胞如何在不同的染色质环境中检测和修复病变仍在深入研究中。与所有与DNA相关的过程一样，NER机制必须处理有组织的染色质的存在及其所呈现的物理障碍。大量的翻译后组蛋白修饰已经被记录下来。虽然对这些修饰的理解还很有限，但它们被认为是许多生物过程的重要调控元件，包括DNA复制和修复，转录和细胞周期控制。其中一些修饰，包括四个核心组蛋白（H2 A，H2 B，H3和H4）或组蛋白H2 A变体H2 AX上的乙酰化，甲基化，磷酸化和泛素化，已被发现与NER过程的不同阶段有关。本文将总结我们最近在这方面的认识。
Histones are highly alkaline proteins that package and order the DNA into chromatin in eukaryotic cells. Nucleotide excision repair (NER) is a conserved multistep reaction that removes a wide range of generally bulky and/or helix-distorting DNA lesions. Although the core biochemical mechanism of NER is relatively well known, how cells detect and repair lesions in diverse chromatin environments is still under intensive research. As with all DNA-related processes, the NER machinery must deal with the presence of organized chromatin and the physical obstacles it presents. A huge catalogue of posttranslational histone modifications has been documented. Although a comprehensive understanding of most of these modifications is still lacking, they are believed to be important regulatory elements for many biological processes, including DNA replication and repair, transcription and cell cycle control. Some of these modifications, including acetylation, methylation, phosphorylation and ubiquitination on the four core histones (H2A, H2B, H3 and H4) or the histone H2A variant H2AX, have been found to be implicated in different stages of the NER process. This review will summarize our recent understanding in this area.
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影响因子：
64.8
作者：
Ernst, Jason;Kheradpour, Pouya;Mikkelsen, Tarjei S.;Shoresh, Noam;Ward, Lucas D.;Epstein, Charles B.;Zhang, Xiaolan;Wang, Li;Issner, Robbyn;Coyne, Michael;Ku, Manching;Durham, Timothy;Kellis, Manolis;Bernstein, Bradley E.
通讯作者：
Bernstein, Bradley E.
DOI：
10.1126/science.1135862
发表时间：
2007-02-02
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Driscoll R;Hudson A;Jackson SP
通讯作者：
Jackson SP
影响因子：
3.8
作者：
Bostelman, Lindsey J.;Keller, Andrew M.;Thompson, Jeffrey S.
通讯作者：
Thompson, Jeffrey S.
影响因子：
4.7
作者：
Cao J;Yan Q
通讯作者：
Yan Q
影响因子：
16
作者：
Clements, A;Poux, AN;Marmorstein, R
通讯作者：
Marmorstein, R