Diagnosis of latent tuberculosis infection among HIV discordant partners using interferon gamma release assays.
Diagnosis of latent tuberculosis infection among HIV discordant partners using interferon gamma release assays.
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DOI：
10.1186/1471-2334-11-264
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发表时间：
2011-09-30
影响因子：
3.7
通讯作者：
Blumberg HM
中科院分区：
文献类型：
--
作者：
Talati NJ;Gonzalez-Diaz E;Mutemba C;Wendt J;Kilembe W;Mwananyanda L;Chomba E;Allen S;del Rio C;Blumberg HM
关于HIV状态和CD 4计数对用于诊断潜伏性结核感染（LTBI）的干扰素-g释放测定（IGRA）性能的影响的数据有限。进行了一项横断面研究，以评估患病率和风险因素的阳性诊断测试LTBI，结核菌素皮肤试验（TST）和IGRA之间的艾滋病毒不一致的夫妇在赞比亚。共入组596例受试者（298对夫妇）。HIV阳性者的中位CD 4计数为388个细胞/μl（范围51-1330）。HIV阴性者比HIV阳性伴侣更有可能对LTBI进行TST（203对128），QFT（171对109）和TSPOT（156对109）阳性诊断测试。多因素分析显示，HIV阴性是QFT（OR = 2.22，95%CI 1.42 ~ 3.46）和TSPOT（OR = 1.79，95%CI 1.16-2.77）阳性的独立预测因子。在HIV阳性受试者中，CD 4计数≥ 388个细胞/μl与TST（OR = 1.76 95% CI 1.10-2.82）和QFT（OR = 1.71 95% CI 1.06-2.77）阳性相关，但与TSPOT（OR = 1.20 95% CI 0.74-1.94）无关。艾滋病毒感染者对LTBI的TST、QFT和TSPOT诊断试验呈阳性的人数明显较少。CD 4计数< 388 cells/μl的人不太可能有阳性TST或QFT，但不太可能有阳性TSPOT。TSPOT可能比TST或QFT在HIV阳性个体中表现更好。
There is limited data on the effect of HIV status and CD4 counts on performance of Interferon-g Release assays (IGRAs) for diagnosis of latent tuberculosis infection (LTBI). A cross sectional study was conducted to assess the prevalence of and risk factors for a positive diagnostic test for LTBI, using tuberculin skin test (TST) and IGRAs among HIV-discordant couples in Zambia. A total of 596 subjects (298 couples) were enrolled. Median CD4 count among HIV positive persons was 388 cells/μl, (range 51-1330). HIV negative persons were more likely than their HIV positive partner, to have a positive diagnostic test for LTBI with TST (203 vs 128), QFT (171 vs 109) and TSPOT (156 vs. 109). On multivariate analysis, HIV negative status was an independent predictor for a positive QFT (OR = 2.22, 95% CI 1.42- 3.46) and TSPOT (OR = 1.79, 95% CI 1.16-2.77). Among HIV positive subjects a CD4 count ≥ 388 cells/μl was associated with a positive TST (OR = 1.76 95% CI 1.10-2.82) and QFT (OR = 1.71 95% CI 1.06-2.77) but not TSPOT (OR = 1.20 95% CI 0.74-1.94). Persons with HIV had significantly fewer positive diagnostic tests for LTBI with TST, QFT and TSPOT. Persons with a CD4 count < 388 cells/μl were less likely to have a positive TST or QFT, but not less likely to have a positive TSPOT. TSPOT may perform better than TST or QFT in HIV positive individuals.
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DOI：
10.1016/j.diagmicrobio.2010.09.005
发表时间：
2011-01-01
影响因子：
2.9
作者：
Santin, Miguel;Casas, Susana;Podzamczer, Daniel
通讯作者：
Podzamczer, Daniel
影响因子：
24.3
作者：
Leidl, L.;Mayanja-Kizza, H.;Lange, C.
通讯作者：
Lange, C.
影响因子：
3.8
作者：
Allen, S;Meinzen-Derr, L;Haworth, A
通讯作者：
Haworth, A
影响因子：
120.7
作者：
ANTONUCCI, G;GIRARDI, E;IPPOLITO, G
通讯作者：
IPPOLITO, G
影响因子：
168.9
作者：
PAPE, JW;JEAN, SS;JOHNSON, WD
通讯作者：
JOHNSON, WD