Thalamic functional connectivity and its association with behavioral performance in older age.
Thalamic functional connectivity and its association with behavioral performance in older age.
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DOI：
10.1002/brb3.943
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发表时间：
2018-04
影响因子：
3.1
通讯作者：
Bagshaw AP
中科院分区：
文献类型：
--
作者：
Goldstone A;Mayhew SD;Hale JR;Wilson RS;Bagshaw AP
尽管丘脑与皮质和皮质下结构都有密集的连接，但很少有研究专门探讨丘脑连接如何随年龄变化以及这种变化与行为的关联。本研究调查了年龄对丘脑 - 皮质和丘脑 - 海马功能连接（FC）的影响，以及丘脑FC与老年人视觉 - 空间记忆和反应时间（RT）表现之间的关联。
从年轻（n = 20）和年长（n = 20）的成年人中获取了静息态功能磁共振图像。采用基于种子的方法来评估丘脑与（1）感觉静息态网络；（2）海马之间的FC。参与者还完成了来自剑桥神经心理测试自动化成套测验（CANTAB）的视觉 - 空间记忆和RT任务。
老年人在感觉丘脑亚区与相应感觉皮质之间的FC特异性丧失。老年人中更强的丘脑 - 运动FC与更快的反应时间相关。此外，与年轻人相比，老年人表现出更强的丘脑 - 海马FC，在视觉 - 空间记忆表现最差的老年人中这种情况最为明显。
尽管与年轻人相比，老年人表现出较差的视觉 - 空间记忆和较慢的反应时间，但“表现好”和“表现较差”的老年人在丘脑 - 皮质和丘脑 - 海马FC方面呈现出不同的模式。这些结果凸显了丘脑连接在支持衰老过程中的反应时间和记忆方面的潜在作用。此外，这些结果强调了在衰老研究中纳入丘脑的重要性，以充分了解大脑随年龄的变化如何与行为相关联。
Despite the thalamus’ dense connectivity with both cortical and subcortical structures, few studies have specifically investigated how thalamic connectivity changes with age and how such changes are associated with behavior. This study investigated the effect of age on thalamo‐cortical and thalamo‐hippocampal functional connectivity (FC) and the association between thalamic FC and visual–spatial memory and reaction time (RT) performance in older adults. Resting‐state functional magnetic resonance images were obtained from younger (n = 20) and older (n = 20) adults. A seed‐based approach was used to assess the FC between the thalamus and (1) sensory resting‐state networks; (2) the hippocampus. Participants also completed visual–spatial memory and RT tasks, from the Cambridge Neuropsychological Test Automated Battery (CANTAB). Older adults exhibited a loss of specificity in the FC between sensory thalamic subregions and corresponding sensory cortex. Greater thalamo‐motor FC in older adults was associated with faster RTs. Furthermore, older adults exhibited greater thalamo‐hippocampal FC compared to younger adults, which was greatest for those with the poorest visual–spatial memory performance. Although older adults exhibited poorer visual–spatial memory and slower reaction times compared to younger adults, “good” and “poorer” older performers exhibited different patterns of thalamo‐cortical and thalamo‐hippocampal FC. These results highlight the potential role of thalamic connectivity in supporting reaction times and memory in aging. Furthermore, these results highlight the importance of including the thalamus in studies of aging to fully understand how brain changes with age may be associated with behavior.
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额顶认知控制网络的年龄差异：对注意力分散的影响。
影响因子：
2.6
作者：
Campbell KL;Grady CL;Ng C;Hasher L
通讯作者：
Hasher L
DOI：
10.1093/brain/awu270
发表时间：
2014-12
期刊：
Brain : a journal of neurology
影响因子：
--
作者：
Duss SB;Reber TP;Hänggi J;Schwab S;Wiest R;Müri RM;Brugger P;Gutbrod K;Henke K
通讯作者：
Henke K
影响因子：
3.7
作者：
Baltes, PB;Lindenberger, U
通讯作者：
Lindenberger, U
影响因子：
3.7
作者：
Davis, Simon W.;Dennis, Nancy A.;Cabeza, Roberto
通讯作者：
Cabeza, Roberto
影响因子：
5.7
作者：
Bruecke, Christof;Bock, Antje;Kuehn, Andrea A.
通讯作者：
Kuehn, Andrea A.