Enzymatic total synthesis of defucogilvocarcin M and its implications for gilvocarcin biosynthesis.
Enzymatic total synthesis of defucogilvocarcin M and its implications for gilvocarcin biosynthesis.
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DOI：
10.1002/anie.201105882
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发表时间：
2012-01-27
影响因子：
16.6
通讯作者：
Rohr, Juergen
中科院分区：
文献类型：
--
作者：
Pahari, Pallab;Kharel, Madan K.;Shepherd, Micah D.;van Lanen, Steven G.;Rohr, Juergen
Gilvocarcin V （GV, 4）是灰黄链霉菌Gö 3592和其他链霉菌的主要代谢物。GV通常与其次要同系物gilvocarcin M(3)和gilvocarcin E(5)一起产生，它们在c8位置的侧链上变化GV的几种类似物（例如，6-8，方案1）被统称为天然产物的gilvocarcin族，已从不同链霉菌物种中分离出来。所有这些类似物都含有聚酮衍生的苯并[d]萘[1,2 -b]吡喃-6- 1发色团，但不同的c -糖苷连接糖单元（方案1）这组天然产物的成员以强大的抗肿瘤活性而闻名，[3]是一种独特的作用方式，[4]和非常低的毒性。[2c， 5]然而，这些分子固有的低溶解度似乎是一个问题
Gilvocarcin V (GV, 4) is the major metabolite of Streptomyces griseoflavus Gö 3592 and various other Streptomyces species. GV is usually produced along with its minor congeners, gilvocarcin M (3) and gilvocarcin E (5), that vary with respect to their side chain at the C8-position.[1] Several analogues of GV (for example, 6–8, Scheme 1), which are collectively called the gilvocarcin group of natural products, have been isolated from different Streptomyces species. All of these analogues contain the characteristic, polyketide-derived benzo [d] naphtho [1, 2-b] pyran-6-one chromophore, but different C-glycosidically linked sugar units Scheme 1).[2] Members of this group of natural products are well-known for strong antitumor activities,[3] a unique mode of action,[4] and remarkably low toxicities.[2c, 5] However, the inherent poor solubility of these molecules appears to be a
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影响因子：
3.2
作者：
Kharel, Madan Kumar;Pahari, Pallab;Lian, Hui;Rohr, Juergen
通讯作者：
Rohr, Juergen
影响因子：
3.2
作者：
Li, Yi-qing;Huang, Xue-shi;Sattler, Isabel
通讯作者：
Sattler, Isabel
影响因子：
3.2
作者：
Liu, Tao;Kharel, Madan Kumar;Rohr, Jurgen
通讯作者：
Rohr, Jurgen
影响因子：
3.3
作者：
MATSUMOTO, A;FUJIWARA, Y;HANAWALT, PC
通讯作者：
HANAWALT, PC
影响因子：
3.3
作者：
MORIMOTO, M;OKUBO, S;MARUMO, H
通讯作者：
MARUMO, H