Platelet function in patients with diabetes mellitus: from a theoretical to a practical perspective.

Platelet function in patients with diabetes mellitus: from a theoretical to a practical perspective.
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DOI:
10.1155/2011/742719
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发表时间:
2011
影响因子:
2.8
通讯作者:
Resar JR
Resar JR
中科院分区:
医学4区
文献类型:
--
作者:
Kakouros N;Rade JJ;Kourliouros A;Resar JR

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糖尿病患者血管疾病发病率增高。与动脉粥样硬化斑块破裂相关的病理性血栓形成是发病率和死亡率的主要原因。血小板与血栓形成的发生和发展密切相关。有证据表明,与健康对照相比,2型糖尿病患者的血小板具有更高的反应性和基线激活。我们回顾了糖尿病患者血小板高反应性的病理生理学及其在临床实践中的意义,特别关注急性冠状动脉综合征、经皮冠状动脉介入治疗和新型抗血小板药物。
Patients with diabetes mellitus have an increased prevalence of vascular disease. Pathologic thrombosis associated with atherosclerotic plaque rupture is a major cause of morbidity and mortality. Platelets are intimately involved in the initiation and propagation of thrombosis. Evidence suggests that platelets from patients with type 2 diabetes have increased reactivity and baseline activation compared to healthy controls. We review the pathophysiology of platelet hyperreactivity in DM patients and its implications in clinical practice, with particular focus on acute coronary syndromes, percutaneous coronary intervention, and novel antiplatelet agents.
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