Strain differences in the effects of chronic corticosterone exposure in the hippocampus.
Strain differences in the effects of chronic corticosterone exposure in the hippocampus.
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DOI：
10.1016/j.neuroscience.2012.06.017
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发表时间：
2012-10-11
期刊：
影响因子：
3.3
通讯作者：
Lucki, I.
中科院分区：
文献类型：
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作者：
Hodes, G. E.;Brookshire, B. R.;Hill-Smith, T. E.;Teegarden, S. L.;Berton, O.;Lucki, I.
关键词：
应激激素被认为与抑郁症的病因有关，部分原因是动物模型显示它们会对大脑造成形态学损伤，这种影响可以通过长期抗抑郁治疗逆转。目前的研究检查了两种小鼠品系选择的自然变化的组织再生损伤后的抵抗慢性皮质酮（CORT）暴露对细胞增殖和神经营养因子动员的影响。伤口愈合者MRL/MpJ和对照C57 BL/6 J小鼠皮下植入释放CORT的丸粒7天。与脆弱的C57 BL/6 J小鼠相比，MRL/MpJ小鼠对慢性暴露于CORT导致的海马细胞增殖减少具有抗性。慢性CORT暴露也降低了C57 BL/6 J小鼠海马中脑源性神经营养因子（BDNF）的蛋白水平，但MRL/MpJ小鼠没有。CORT颗粒暴露以剂量依赖性方式增加了两种品系血浆中CORT的循环水平，尽管MRL/MpJ小鼠可能较基线有较大变化。菌株没有不同的循环水平的皮质酮结合球蛋白（CBG）。海马中CORT水平也没有应变差异，也没有CORT暴露改变糖皮质激素受体或盐皮质激素受体表达的应变依赖性方式。在NMDA受体和BDNF I和IV启动子中发现了菌株差异。应变和CORT暴露相互作用改变原肌氨酸受体激酶B（Trk B）表达，这可能是保护MRL/MpJ小鼠的潜在机制。此外，基质金属蛋白酶（MMPs）的炎症反应的差异也可能导致这些菌株对CORT对大脑有害作用的抵抗力差异。
Stress hormones are thought to be involved in the etiology of depression, in part, because animal models show they cause morphological damage to the brain, an effect that can be reversed by chronic antidepressant treatment. The current study examined two mouse strains selected for naturalistic variation of tissue regeneration after injury for resistance to the effects of chronic corticosterone (CORT) exposure on cell proliferation and neurotrophin mobilization. The wound healer MRL/MpJ and control C57BL/6J mice were implanted subcutaneously with pellets that released CORT for 7 days. MRL/MpJ mice were resistant to reductions of hippocampal cell proliferation by chronic exposure to CORT when compared to vulnerable C57BL/6J mice. Chronic CORT exposure also reduced protein levels of brain derived neurotrophic factor (BDNF) in the hippocampus of C57BL/6J but not MRL/MpJ mice. CORT pellet exposure increased circulating levels of CORT in the plasma of both strains in a dose dependent manner although MRL/MpJ mice may have larger changes from baseline. The strains did not differ in circulating levels of corticosterone binding globulin (CBG). There were also no strain differences in CORT levels in the hippocampus, nor did CORT exposure alter glucocorticoid receptor or mineralocorticoid receptor expression in a strain dependent manner. Strain differences were found in the NMDA receptor, and BDNF I and IV promoter. Strain and CORT exposure interacted to alter tropomyosine-receptor- kinase B (TrkB) expression and this may be potential mechanism protecting MRL/MpJ mice. In addition, differences in the inflammatory response of matrix metalloproteinases (MMPs) may also contribute to these strain differences in resistance to the deleterious effects of CORT to the brain.
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影响因子：
2.3
作者：
Benekareddy, Madhurima;Mehrotra, Purvi;Vaidya, Vidita A.
通讯作者：
Vaidya, Vidita A.
影响因子：
3.7
作者：
Chang, Ya-Ting;Chen, Yi-Chieh;Kuo, Yu-Min
通讯作者：
Kuo, Yu-Min
DOI：
10.1017/s1461145708008997
发表时间：
2009-02-01
影响因子：
4.8
作者：
Fuchikami, Manabu;Morinobu, Shigeru;Yamawaki, Shigeto
通讯作者：
Yamawaki, Shigeto
影响因子：
8.2
作者：
Balu, Darrick T.;Lucki, Irwin
通讯作者：
Lucki, Irwin
DOI：
10.1038/npp.2008.123
发表时间：
2009-02
期刊：
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
影响因子：
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作者：
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