Clinical, pathological and prognostic characteristics of gastroenteropancreatic neuroendocrine neoplasms in China: a retrospective study.
Clinical, pathological and prognostic characteristics of gastroenteropancreatic neuroendocrine neoplasms in China: a retrospective study.
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中国胃肠胰神经内分泌肿瘤的临床、病理和预后特征：回顾性研究
DOI：
10.1186/1472-6823-14-54
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发表时间：
2014-07-08
影响因子：
2.7
通讯作者：
Gong P
中科院分区：
文献类型：
--
作者：
Zhang X;Ma L;Bao H;Zhang J;Wang Z;Gong P
背景胃肠胰腺神经内分泌肿瘤（GEP-NEN）是一种罕见的神经内分泌肿瘤，在亚洲人群尤其是中国缺乏相关数据。本回顾性研究的目的是评估GEP-NENs在中国的临床，病理和预后特征。方法收集2003年1月至2012年12月在大连医科大学附属第一医院和第二医院诊断为GEP-NENs的168例患者的临床和病理资料。采用Kaplan-Meier法和logrank法分析临床和病理特征对预后的影响。结果平均年龄为51.83 ± 14.03岁，男女比例为1.5：1。主要部位为直肠（58.93%）、胰腺（13.69%）、胃（9.52%）、十二指肠（5.36%）、结肠（4.76%）、阑尾（4.76%）、回肠（2.38%）和空肠（0.60%）。绝大多数患者（95.83%）表现为非功能性肿瘤，临床症状无特异性，如腹痛或背痛（29.17%）和消化道出血（25.60%）。根据2010年世界卫生组织（WHO）分类，患者被诊断为神经内分泌肿瘤（NET）（24.40%）或神经内分泌癌（NEC）（7.14%）。估计的平均生存期为8.94 ± 0.28年（95%CI：8.40-9.48）。男性、年轻、肿瘤体积小和NET肿瘤类型是有利的预后因素。结论中国GEP-NEN患者的特征与美国和欧洲患者相似。然而，目前迫切需要建立一个全国性的数据库，以了解中国GEP-NEN的临床和流行病学特征。
BackgroundGastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) are rare neuroendocrine tumors, and lack of data in Asian populations especially in China. The aim of this retrospective study was to assess the clinical, pathological and prognostic characteristics of GEP-NENs in China.MethodsWe collected clinical and pathological data of 168 patients diagnosed with GEP-NENs and treated at the First and Second Affiliated Hospitals of Dalian Medical University between January 2003 and December 2012. Kaplan-Meier method and log rank analysis was used to analyze the prognostic significance of clinical and pathological characteristics.ResultsMean age was 51.83 ± 14.03 and the male-to-female ratio was 1.5:1. Primary sites were the rectum (58.93%), pancreas (13.69%), stomach (9.52%), duodenum (5.36%), colon (4.76%), appendix (4.76%), ileum (2.38%) and jejunum (0.60%). Most patients (95.83%) presented non-functional tumors with non-specific symptoms such as abdominal or back pain (29.17%) and gastrointestinal bleeding (25.60%). Based on the 2010 World Health Organization (WHO) classification, patients were diagnosed with neuroendocrine tumor (NET) (24.40%) or neuroendocrine carcinoma (NEC) (7.14%). The estimated mean survival was 8.94 ± 0.28 years (95% CI: 8.40-9.48). Male gender, young age, small tumor size and NET tumor type were favorable prognostic factors.ConclusionChinese GEP-NENs patients present characteristics that are similar to American and European patients. However, there is an urgent need to establish a national database for understanding the clinical and epidemiological features of GEP-NENs in China.
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影响因子：
45.3
作者：
Sun, WJ;Lipsitz, S;Haller, DG
通讯作者：
Haller, DG
影响因子：
6.2
作者：
Pape, Ulrich-Frank;Jann, Henning;Wiedenmann, Bertram
通讯作者：
Wiedenmann, Bertram
影响因子：
3.4
作者：
Garcia-Carbonero, Rocio;Salazar, Ramon;Isla, Dolores
通讯作者：
Isla, Dolores
影响因子：
29.4
作者：
Lepage, Come;Rachet, Bernard;Coleman, Michel Philippe
通讯作者：
Coleman, Michel Philippe
影响因子：
6.2
作者：
Hauso, Oyvind;Gustafson, Bjorn I.;Modlin, Irvin M.
通讯作者：
Modlin, Irvin M.