Skeletal muscle-secreted DLPC orchestrates systemic energy homeostasis by enhancing adipose browning.
Skeletal muscle-secreted DLPC orchestrates systemic energy homeostasis by enhancing adipose browning.
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DOI：
10.1038/s41467-023-43402-z
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发表时间：
2023-11-30
影响因子：
16.6
通讯作者：
Zhu, Dahai
中科院分区：
文献类型：
--
作者：
Hu, Xiaodi;Sun, Mingwei;Chen, Qian;Zhao, Yixia;Liang, Na;Wang, Siyuan;Yin, Pengbin;Yang, Yuanping;Lam, Sin Man;Zhang, Qianying;Tudiyusufu, Alimujiang;Gu, Yingying;Wan, Xin;Chen, Meihong;Li, Hu;Zhang, Xiaofei;Shui, Guanghou;Fu, Suneng;Zhang, Licheng;Tang, Peifu;Wong, Catherine C. L.;Zhang, Yong;Zhu, Dahai
MyoD是一种骨骼肌特异表达的转录因子，在肌肉发育和再生过程中起着重要的调控作用。然而，肌纤维表达的MyoD是否在体内调节全身能量动态平衡方面发挥其代谢功能仍是一个很大的未知数。在这里，我们报告了雄性小鼠的Myod基因缺失增强了肌肉的氧化代谢，有趣的是，使雄性小鼠对高脂饮食诱导的肥胖具有抵抗力。通过在肌肉条件培养液和血清中进行脂肪组学分析，我们确定1，2-二烯油酰-sn-甘油-3-磷酸胆碱(DLPC)是一种肌肉释放的脂质，负责MyoD协调的雄性Myod KO小鼠体内能量平衡。从功能上讲，给予DLPC显著改善了高脂饲料诱导的雄性小鼠的肥胖。机制上，DLPC被发现通过脂质过氧化介导的p38信号在雄性小鼠中诱导白色脂肪褐变。总之，我们的发现不仅揭示了MyoD通过肌源性脂肪因子DLPC控制全身能量动态平衡的新功能，还表明DLPC可能具有治疗人类肥胖的临床潜力。MyoD是一种在骨骼肌中表达的转录因子，在决定肌源性细胞命运中起着关键作用。在这里，胡等人。揭示MyoD在协调全身能量平衡中的代谢作用，通过肌肉分泌的脂肪因子DLPC介导肌肉-脂肪串扰。
MyoD is a skeletal muscle-specifically expressed transcription factor and plays a critical role in regulating myogenesis during muscle development and regeneration. However, whether myofibers-expressed MyoD exerts its metabolic function in regulating whole body energy homeostasis in vivo remains largely unknown. Here, we report that genetic deletion of Myod in male mice enhances the oxidative metabolism of muscle and, intriguingly, renders the male mice resistant to high fat diet-induced obesity. By performing lipidomic analysis in muscle-conditioned medium and serum, we identify 1,2-dilinoleoyl-sn-glycero-3-phosphocholine (DLPC) as a muscle-released lipid that is responsible for MyoD-orchestrated body energy homeostasis in male Myod KO mice. Functionally, the administration of DLPC significantly ameliorates HFD-induced obesity in male mice. Mechanistically, DLPC is found to induce white adipose browning via lipid peroxidation-mediated p38 signaling in male mice. Collectively, our findings not only uncover a novel function of MyoD in controlling systemic energy homeostasis through the muscle-derived lipokine DLPC but also suggest that the DLPC might have clinical potential for treating obesity in humans. MyoD is a transcription factor expressed in skeletal muscle that plays a critical role in determining myogenic cell fate. Here, Hu et al. reveal a metabolic role of MyoD in orchestrating systemic energy homeostasis by mediating muscle-fat crosstalk through the muscle-secreted lipokine DLPC.
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影响因子：
64.5
作者：
Cao H;Gerhold K;Mayers JR;Wiest MM;Watkins SM;Hotamisligil GS
通讯作者：
Hotamisligil GS
定量脂质组学和空间 MS 成像揭示了洞穴鱼类类形适应背后的神经和系统脂质代谢途径
影响因子：
10.7
作者：
Lam, Sin Man;Li, Jie;Sun, Huan;Mao, Weining;Lu, Zongmin;Zhao, Qingshuo;Han, Chao;Gong, Xia;Jiang, Binhua;Chua, Gek Huey;Zhao, Zhenwen;Meng, Fanwei;Shui, Guanghou
通讯作者：
Shui, Guanghou
影响因子：
7.7
作者：
Floegel A;Stefan N;Yu Z;Mühlenbruch K;Drogan D;Joost HG;Fritsche A;Häring HU;Hrabě de Angelis M;Peters A;Roden M;Prehn C;Wang-Sattler R;Illig T;Schulze MB;Adamski J;Boeing H;Pischon T
通讯作者：
Pischon T
影响因子：
--
作者：
Ayala A;Muñoz MF;Argüelles S
通讯作者：
Argüelles S
DOI：
10.1186/s13619-021-00093-5
发表时间：
2021-10-01
期刊：
Cell regeneration (London, England)
影响因子：
--
作者：
Esteves de Lima J;Relaix F
通讯作者：
Relaix F