Emerging roles of T helper subsets in the pathogenesis of asthma.
Emerging roles of T helper subsets in the pathogenesis of asthma.
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DOI：
10.3109/08820131003615498
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发表时间：
2010
影响因子：
2.8
通讯作者：
Metzger DW
中科院分区：
文献类型：
--
作者：
Durrant DM;Metzger DW
哮喘的主要特征包括肺部炎症和气道高反应性（AHR）。传统上，哮喘，特别是过敏性哮喘，被归因于过度活跃的 Th2 细胞免疫反应。然而，Th2 细胞介导的炎症模型未能充分解释哮喘的许多临床和分子方面。此外，Th2 靶向治疗试验的结果也令人失望。因此，哮喘现在被认为是一种复杂且异质的疾病，具有与哮喘相关的气道炎症和 AHR 的多种分子机制。 Th1 和 Th2 通路的原始分类最近已扩展到包括其他效应 Th 细胞亚群。这些细胞包括 Th17、Th9 和 Treg 细胞。新出现的数据强调了这些新的 Th 细胞亚群参与气道炎症和哮喘反应的引发和增强。我们现在回顾这些最近分类的效应 Th 细胞亚群在哮喘炎症中的作用，以及除了传统 Th2 范式之外它们可能提供的见解。希望更清楚地了解所涉及的炎症途径和炎症介质将产生更好的靶向治疗。
The cardinal features of asthma include pulmonary inflammation and airway hyperresponsiveness (AHR). Classically, asthma, specifically allergic asthma, has been attributed to a hyperactive Th2 cell immune response. However, the Th2 cell-mediated inflammation model has failed to adequately explain many of the clinical and molecular aspects of asthma. In addition, the outcomes of Th2-targeted therapeutic trials have been disappointing. Thus, asthma is now believed to be a complex and heterogeneous disorder, with several molecular mechanisms underlying the airway inflammation and AHR that is associated with asthma. The original classification of Th1 and Th2 pathways has recently been expanded to include additional effector Th cell subsets. These include Th17, Th9 and Treg cells. Emerging data highlight the involvement of these new Th cell subsets in the initiation and augmentation of airway inflammation and asthmatic responses. We now review the roles of these recently classified effector Th cell subsets in asthmatic inflammation and the insights they may provide in addition to the traditional Th2 paradigm. The hope is that a clearer understanding of the inflammatory pathways involved and the mediators of inflammation will yield better targeted therapeutics.
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影响因子：
64.8
作者：
Bettelli, E;Carrier, YJ;Kuchroo, VK
通讯作者：
Kuchroo, VK
DOI：
10.1164/rccm.2105079
发表时间：
2002-08-01
影响因子：
24.7
作者：
Cheng, G;Arima, M;Fukuda, T
通讯作者：
Fukuda, T
影响因子：
4.3
作者：
Barczyk, A;Pierzchala, W;Sozañska, E
通讯作者：
Sozañska, E
影响因子：
32.4
作者：
Barrett, Nora A.;Austen, K. Frank
通讯作者：
Austen, K. Frank
DOI：
10.1164/ajrccm/147.2.291
发表时间：
1993-02-01
期刊：
AMERICAN REVIEW OF RESPIRATORY DISEASE
影响因子：
--
作者：
CEMBRZYNSKANOWAK, M;SZKLARZ, E;TEODORCZYKINJEYAN, JA
通讯作者：
TEODORCZYKINJEYAN, JA