The involvement of heat-shock proteins in the pathogenesis of autoimmune arthritis: a critical appraisal.
The involvement of heat-shock proteins in the pathogenesis of autoimmune arthritis: a critical appraisal.
复制标题
DOI：
10.1016/j.semarthrit.2009.10.002
复制
发表时间：
2010-10
影响因子：
5
通讯作者：
Moudgil, Kamal D.
中科院分区：
文献类型：
--
作者：
Huang, Min-Nung;Yu, Hua;Moudgil, Kamal D.
To review the literature on the role of heat-shock proteins (HSPs) in the pathogenesis of autoimmune arthritis in animal models ans patients with rheumatoid arthritis (RA). The published literature in Medline (PubMed), including our published work on the cell-mediated as well as humoral immune response to various HSPs was reviewed. Studies in both the pre-clinical animal models of arthritis as well as RA were examined critically and the data presented. In experimental arthritis, disease induction by different arthritogenic stimuli, including an adjuvant, led to immune response to mycobacterial HSP65 (BHSP65). However, attempts to induce arthritis by a purified HSP have not met with success. There are several reports of a significant immune response to HSP65 in RA patients. But, the issue of cause and effect is difficult to address. Nevertheless, several studies in animal models and a couple of clinical trials in RA patients have shown the beneficial effect of HSPs against autoimmune arthritis. There is a clear association between immune response to HSPs, particularly HSP65, and the initiation and propagation of autoimmune arthritis in experimental models. The correlation is relatively less convincing in RA patients. In both cases, the ability of HSPs to modulate arthritis offers support, albeit an indirect one, for the involvement of these antigens in the disease process.
登录
查看更多内容
影响因子：
4.9
作者：
Dasuri K;Antonovici M;Chen K;Wong K;Standing K;Ens W;El-Gabalawy H;Wilkins JA
通讯作者：
Wilkins JA
影响因子：
4.4
作者：
Corrigall, VM;Bodman-Smith, MD;Panayi, GS
通讯作者：
Panayi, GS
影响因子：
--
作者：
Brownlie, RJ;Myers, LK;Thompson, SJ
通讯作者：
Thompson, SJ
影响因子：
5.5
作者：
Bodman-Smith, MD;Corrigall, VM;Panayi, GS
通讯作者：
Panayi, GS
DOI：
10.1073/pnas.0904489106
发表时间：
2009-08-25
影响因子：
11.1
作者：
Clayton, T. Andrew;Baker, David;Nicholson, Jeremy K.
通讯作者：
Nicholson, Jeremy K.