Genome-wide association study identifies three new susceptibility loci for adult asthma in the Japanese population.
Genome-wide association study identifies three new susceptibility loci for adult asthma in the Japanese population.
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哮喘是一种常见的炎症性疾病，由遗传因素和环境因素相互作用引起。通过全基因组关联研究和重复研究，在日本人群中，共有7171名成人哮喘患者(病例)和27912名对照，我们确定了5个与成人哮喘易感性相关的基因座。除已报道的主要组织相容性复合体和TSLP-WDR36基因座外，我们还发现了另外三个基因座：4q31上的USP38-GAB1基因座(联合P=1.87×10−12)，10p14上的一个基因座(P=1.79×10−15)和12q13上的基因富集区(P=2.33×10−13)。我们观察到主要组织相容性复合体区域的rs404860与成人哮喘的相关性最显著(P=4.07×10−23)，这与先前在全基因组肺功能相关性研究中报道的rs2070600与FEV1/FVC相关。我们的发现为更好地理解哮喘易感性的基因贡献提供了更好的理解。
Bronchial asthma is a common inflammatory disease caused by the interaction of genetic and environmental factors,. Through a genome-wide association study and a replication study consisting of a total of 7,171 individuals with adult asthma (cases) and 27,912 controls in the Japanese population, we identified five loci associated with susceptibility to adult asthma. In addition to the major histocompatibility complex andTSLP-WDR36loci previously reported, we identified three additional loci: aUSP38-GAB1locus on chromosome 4q31 (combinedP= 1.87 × 10−12), a locus on chromosome 10p14 (P= 1.79 × 10−15) and a gene-rich region on chromosome 12q13 (P= 2.33 × 10−13). We observed the most significant association with adult asthma at rs404860 in the major histocompatiblity complex region (P= 4.07 × 10−23), which is close to rs2070600, a SNP previously reported for association with FEV1/FVC in genome-wide association studies for lung function. Our findings offer a better understanding of the genetic contribution to asthma susceptibility.
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影响因子：
7.7
作者：
Hakonarson, Hakon;Qu, Hui-Qi;Polychronakos, Constantin
通讯作者：
Polychronakos, Constantin
影响因子：
5.2
作者：
Moffatt, MF;Schou, C;Cookson, WOCM
通讯作者：
Cookson, WOCM
影响因子：
30.8
作者：
Repapi, Emmanouela;Sayers, Ian;Tobin, Martin D.
通讯作者：
Tobin, Martin D.
DOI：
10.1038/nri2476
发表时间：
2009-02
期刊：
Nature reviews. Immunology
影响因子：
--
作者：
通讯作者：
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影响因子：
9.8
作者：
Luca, Diana;Ringquist, Steven;Trucco, Massimo
通讯作者：
Trucco, Massimo