Elastomeric high-mineral content hydrogel-hydroxyapatite composites for orthopedic applications.
Elastomeric high-mineral content hydrogel-hydroxyapatite composites for orthopedic applications.
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DOI：
10.1002/jbm.a.32110
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发表时间：
2009-06-15
影响因子：
4.9
通讯作者：
Bertozzi, Carolyn R.
中科院分区：
文献类型：
--
作者：
Song, Jie;Xu, Jianwen;Filion, Tera;Saiz, Eduardo;Tomsia, Antoni P.;Lian, Jane B.;Stein, Gary S.;Ayers, David C.;Bertozzi, Carolyn R.
关键词：
模拟骨的结构和组成并具有良好的手术操作特性的合成骨移植物的设计仍然是一个重大挑战。我们报告了聚（甲基丙烯酸2-羟乙酯）（pHEMA）-羟基磷灰石（HA）复合材料的开发，称为“FlexBone”，具有骨传导矿物质含量接近人骨，但表现出弹性体性能，使压配合到缺损部位。该方法涉及使用粘性乙二醇作为溶剂在HA存在下交联pHEMA水凝胶。该复合材料在磷灰石矿物成分和羟基化水凝胶基质之间表现出优异的结构整合。复合材料的刚度和承受压缩应力的能力与矿物组分的微观结构和含量相关。结合多孔聚集体的HA纳米晶体，而不是紧凑的微米级煅烧HA有效地提高了抗裂纹扩展的复合材料在压缩下。含有50wt%多孔HA纳米晶体的冷冻干燥FlexBone可以承受数百兆帕斯卡的压缩应力和>80%的压缩应变而不表现出脆性断裂。在与水平衡后，FlexBone保持良好的结构整合，并在体温下承受重复中等（兆帕斯卡）压缩应力。当皮下植入大鼠时，FlexBone支持预先接种在FlexBone上的骨髓基质细胞的成骨分化。综上所述，高骨传导矿物质含量、优异的有机-无机结构整合、弹性和支持体内成骨细胞分化的能力的组合使FlexBone成为骨科应用的有希望的候选物。
The design of synthetic bone grafts that mimic the structure and composition of bone and possess good surgical handling characteristics remains a major challenge. We report the development of poly(2-hydroxyethyl methacrylate) (pHEMA)-hydroxyapatite (HA) composites termed “FlexBone” that possess osteoconductive mineral content approximating that of human bone yet exhibit elastomeric properties enabling the press-fitting into a defect site. The approach involves crosslinking pHEMA hydrogel in the presence of HA using viscous ethylene glycol as a solvent. The composites exhibit excellent structural integration between the apatite mineral component and the hydroxylated hydrogel matrix. The stiffness of the composite and the ability to withstand compressive stress correlate with the microstructure and content of the mineral component. The incorporation of porous aggregates of HA nanocrystals rather than compact micrometer-sized calcined HA effectively improved the resistance of the composite to crack propagation under compression. Freeze-dried FlexBone containing 50 wt % porous HA nanocrystals could withstand hundreds-of-megapascals compressive stress and >80% compressive strain without exhibiting brittle fractures. Upon equilibration with water, FlexBone retained good structural integration and withstood repetitive moderate (megapascals) compressive stress at body temperature. When subcutaneously implanted in rats, FlexBone supported osteoblastic differentiation of the bone marrow stromal cells pre-seeded on FlexBone. Taken together, the combination of high osteoconductive mineral content, excellent organic-inorganic structural integration, elasticity, and the ability to support osteoblastic differentiation in vivo makes FlexBone a promising candidate for orthopedic applications.
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DOI：
10.1115/1.3138409
发表时间：
1983-01-01
影响因子：
1.7
作者：
AHMED, AM;BURKE, DL
通讯作者：
BURKE, DL
影响因子：
4.1
作者：
Follet, H;Boivin, G;Meunier, PJ
通讯作者：
Meunier, PJ
DOI：
10.1002/jbm.820180411
发表时间：
1984-01-01
期刊：
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH
影响因子：
--
作者：
SAHA, S;PAL, S
通讯作者：
PAL, S
DOI：
10.1007/s11420-005-0111-5
发表时间：
2005-09-01
期刊：
HSS journal : the musculoskeletal journal of Hospital for Special Surgery
影响因子：
--
作者：
Bostrom, Mathias P G;Seigerman, Daniel A
通讯作者：
Seigerman, Daniel A
DOI：
10.1073/pnas.83.9.2879
发表时间：
1986-05-01
影响因子：
11.1
作者：
HODGE, WA;FIJAN, RS;MANN, RW
通讯作者：
MANN, RW