Inflammation and atherosclerosis: direct versus indirect mechanisms.
Inflammation and atherosclerosis: direct versus indirect mechanisms.
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DOI：
10.1016/j.coph.2013.01.003
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发表时间：
2013-04
影响因子：
4
通讯作者：
Rosenfeld, Michael E.
中科院分区：
文献类型：
--
作者：
Rosenfeld, Michael E.
It is now widely accepted that the development of atherosclerotic lesions involves a chronic inflammatory response that includes both innate and adaptive immune mechanisms. However, it is still unclear precisely what induces the inflammatory response. Furthermore, inflammation within the blood vessel can be divided into direct mechanisms where the primary inflammatory events occur within the intima of the blood vessel and contribute to both the initiation and progression of the plaques and indirect mechanisms where inflammation at non-vascular sites can contribute to the progression of the lesions. The direct mechanisms include lipid deposition and modification, influx of lipoprotein associated factors and microparticles derived from many different cell types, and possibly bacterial and viral infection of vascular cells. Indirect mechanisms derive from inflammation related to autoimmune diseases, smoking, respiratory infection, and pollution exposure, and possibly periodontal disease and gastric infection. The mechanisms include secretion of cytokines and other inflammatory factors into the circulation with subsequent uptake into the plaques, egress and recruitment of activated inflammatory cells, formation of dysfunctional HDL and cross reactive autoantibodies.
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影响因子：
4.4
作者：
Adamson S;Leitinger N
通讯作者：
Leitinger N
影响因子：
4.4
作者：
Abela, George S.
通讯作者：
Abela, George S.
具有遗传转换的高脂血症的逆转会影响动脉粥样硬化斑块中巨噬细胞的含量和炎症状态。
影响因子：
37.8
作者：
Feig JE;Parathath S;Rong JX;Mick SL;Vengrenyuk Y;Grauer L;Young SG;Fisher EA
通讯作者：
Fisher EA
影响因子：
0.5
作者：
Agarwal, Neil K.;Sharma, Prerna;Agarwal, Shashi K.
通讯作者：
Agarwal, Shashi K.
影响因子：
4.6
作者：
Curry, AJ;Portig, I;Gaston, JSH
通讯作者：
Gaston, JSH