High induction of phenol UDP-glucuronosyltransferase in the kidney medulla of beta-naphthoflavone-treated rats.
High induction of phenol UDP-glucuronosyltransferase in the kidney medulla of beta-naphthoflavone-treated rats.
复制标题
β-萘黄酮治疗大鼠肾髓质中苯酚 UDP-葡萄糖醛酸基转移酶的高诱导。
DOI：
10.1016/s0304-4165(97)00022-6
复制
发表时间：
1997
期刊：
影响因子：
--
通讯作者：
A. Yuasa
中科院分区：
文献类型：
--
作者：
H. Yokota;H. Inoue;H. Taniyama;T. Kobayashi;H. Iwano;Y. Kagawa;H. Okada;A. Yuasa
β-萘黄酮处理可高度诱导大鼠肾髓质微粒体中的苯酚 UDP-葡萄糖醛酸基转移酶活性。在β-萘黄酮治疗大鼠后，在免疫印迹和Northern印迹分析中，髓质中的苯酚UDP-葡萄糖醛酸基转移酶及其mRNA均大大增加。在未经处理的大鼠肾脏中，通过免疫组织化学分析仅在位于皮质的近端卷积肾小管细胞中检测到苯酚UDP-葡萄糖醛酸基转移酶。 β-萘黄酮治疗大鼠后，髓质远端小管直部上皮细胞中出现UDP-葡萄糖醛酸基转移酶。总之，髓质远端肾小管细胞具有较高的潜在葡萄糖醛酸化活性，被认为在药物排泄中发挥重要作用。
Phenol UDP-glucuronosyltransferase activity was highly induced in the microsomes of the kidney medulla of rats by β-naphthoflavone treatment. In the medulla, phenol UDP-glucuronosyltransferase and its mRNA were greatly increased in both immunoblotting and Northern blot analyses following β-naphthoflavone treatment of the rats. In untreated rat kidneys, phenol UDP-glucuronosyltransferase was detected by immunohistochemical analysis only in proximal convolution tubular cells located in the cortex. After β-naphthoflavone treatment of the rats, UDP-glucuronosyltransferase appeared in the epithelial cells in the straight portion of the distal tubules located in the medulla. In conclusion, the medullary distal tubular cells have high latent glucuronidation activity and are thought to play an important role in drug excretion.
UDP葡萄糖醛酸基转移酶在大鼠组织中的分布。
DOI：
10.1073/pnas.82.9.2990
发表时间：
1985
影响因子：
11.1
作者：
Chowdhury,JR;Novikoff,PM;Chowdhury,NR;Novikoff,AB
通讯作者：
Novikoff,AB