The nuclear signaling of NF-kappaB: current knowledge, new insights, and future perspectives.
The nuclear signaling of NF-kappaB: current knowledge, new insights, and future perspectives.
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核因子-κ B（NF-κB）转录因子在与增殖、细胞死亡、发育以及先天性和适应性免疫应答相关的多种细胞过程中起关键作用。NF-κB通常被称为Iκ B的抑制蛋白家族隔离在细胞质中。在过去的二十年中，导致NF-κB释放和核积聚的信号通路被广泛研究，NF-κB B可以被各种刺激激活。进入细胞核后，NF-κB必须受到主动调节，以执行其作为转录因子的基本功能。最近的研究强调了核信号在NF-κB转录活性调节中的重要性。NF-κB的非Rel亚基、核糖体蛋白S3（RPS 3）和NF-κB的许多其他核调节剂（包括Akirin、Nurr 1、SIRT 6等）最近被鉴定，揭示了核中NF-κB的新的和令人兴奋的调节特异性层。进一步了解控制NF-κB B功能的核事件将加深我们对其转录活性的精确控制的理解，并更好地为NF-κ B相关疾病的治疗方法的潜在合理设计提供信息。
The nuclear factor-kappa B (NF-κB) transcription factor plays a critical role in diverse cellular processes associated with proliferation, cell death, development, as well as innate and adaptive immune responses. NF-κB is normally sequestered in the cytoplasm by a family of inhibitory proteins known as IκBs. The signal pathways leading to the liberation and nuclear accumulation of NF-κB, which can be activated by a wide variety of stimuli, have been extensively studied in the past two decades. After gaining access to the nucleus, NF-κB must be actively regulated to execute its fundamental function as a transcription factor. Recent studies have highlighted the importance of nuclear signaling in the regulation of NF-κB transcriptional activity. A non-Rel subunit of NF-κB, ribosomal protein S3 (RPS3), and numerous other nuclear regulators of NF-κB including Akirin, Nurr1, SIRT6, and others, have recently been identified, unveiling novel and exciting layers of regulatory specificity for NF-κB in the nucleus. Further insights into the nuclear events that govern NF-κB function will deepen our understanding of the elegant control of its transcriptional activity and better inform the potential rational design of therapeutics for NF-κB-associated diseases.
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