Magnetic resonance imaging for N staging in non-small cell lung cancer: A systematic review and meta-analysis.
Magnetic resonance imaging for N staging in non-small cell lung cancer: A systematic review and meta-analysis.
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DOI：
10.1111/1759-7714.12203
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发表时间：
2015-03
期刊：
影响因子：
2.9
通讯作者：
Zhang K
中科院分区：
文献类型：
--
作者：
Zhang Y;Qin Q;Li B;Wang J;Zhang K
非小细胞肺癌（NSCLC）的淋巴结分期对于决定适当的治疗至关重要。本研究系统地回顾了关于磁共振成像（MRI）在NSCLC患者淋巴结分期中的诊断性能的文献，并确定了其合并的敏感性和特异性。使用PubMed和Embase数据库以及科克伦图书馆检索相关研究。两名评审员独立确定了每项研究的方法学质量。对每项研究报告的敏感性和特异性进行荟萃分析。纳入了9项研究。这些研究具有中等至良好的方法学质量。基于每例患者分析的合并灵敏度、特异性、阳性似然比（LR+）、阴性似然比（LR-）和诊断比值比（DOR）（7项研究）分别为74%、90%、7.5%、0.26%和36.7%，基于每淋巴结的分析分别为74%、90%、7.5%、0.26%和36.7%。（5项研究）分别为77%、98%、42.24、0.21和212.35。对于定量短时反转恢复成像（STIR）和弥散加权成像（DWI）的荟萃分析，合并的敏感性和特异性分别为84%和91%，69%和93%。合并LR+和合并LR−分别为8.44和0.18，以及8.36和0.36。DOR分别为56.29和27.2。MRI对NSCLC的淋巴结分期具有较高的特异性。定量STIR的DOR大于定量DWI。需要进行大规模、直接和前瞻性研究来比较STIR与DWI的诊断能力;应建立一致的诊断标准。
Lymph node staging in non-small cell lung cancer (NSCLC) is essential for deciding appropriate treatment. This study systematically reviews the literature regarding the diagnostic performance of magnetic resonance imaging (MRI) in lymph node staging of patients with NSCLC, and determines its pooled sensitivity and specificity. PubMed and Embase databases and the Cochrane library were used to search for relevant studies. Two reviewers independently identified the methodological quality of each study. A meta-analysis of the reported sensitivity and specificity of each study was performed. Nine studies were included. These studies had moderate to good methodological quality. Pooled sensitivity, specificity, positive likelihood ratio (LR+), negative likelihood ratio (LR−) and diagnosis odds ratio (DOR) for per-patient based analyses (7 studies) were 74%, 90%, 7.5, 0.26, and 36.7, respectively, and those for per-lymph node based analyses (5 studies) were 77%, 98%, 42.24, 0.21, and 212.35, respectively. For meta-analyses of quantitative short time inversion recovery imaging (STIR) and diffusion-weighted imaging (DWI), pooled sensitivity and specificity were 84% and 91%, and 69% and 93%, respectively. Pooled LR+ and pooled LR− were 8.44 and 0.18, and 8.36 and 0.36, respectively. The DOR was 56.29 and 27.2 respectively. MRI showed high specificity in the lymph node staging of NSCLC. Quantitative STIR has greater DOR than quantitative DWI. Large, direct, and prospective studies are needed to compare the diagnostic power of STIR versus DWI; consistent diagnostic criteria should be established.
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影响因子：
5.9
作者：
Kim, Yoo Na;Yi, Chin A.;Shim, Young Mog
通讯作者：
Shim, Young Mog
影响因子：
5
作者：
LEVITT, RG;GLAZER, HS;MURPHY, WA
通讯作者：
MURPHY, WA
影响因子：
2.1
作者：
GEORGIAN, D;RICE, TW;ODONOVAN, PB
通讯作者：
ODONOVAN, PB
影响因子：
9.6
作者：
Halpern, BS;Schiepers, C;Czernin, J
通讯作者：
Czernin, J
DOI：
10.6004/jnccn.2012.0062
发表时间：
2012-05-01
影响因子：
13.4
作者：
Martins, Renato G.;D'Amico, Thomas A.;Wood, Douglas E.
通讯作者：
Wood, Douglas E.