Male gender is a predictor of higher mortality in hospitalized adults with COVID-19.
Male gender is a predictor of higher mortality in hospitalized adults with COVID-19.
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DOI：
10.1371/journal.pone.0254066
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发表时间：
2021
期刊：
影响因子：
3.7
通讯作者：
Amin A
中科院分区：
文献类型：
--
作者：
Nguyen NT;Chinn J;De Ferrante M;Kirby KA;Hohmann SF;Amin A
冠状病毒病2019(新冠肺炎)大流行仍然是一个全球威胁，投入了大量资源来确定严重新冠肺炎疾病的风险因素。这项研究的目的是分析需要在美国学术中心住院的成年新冠肺炎患者的男性和女性的特征和结果。使用Vizient临床数据库，回顾了2020年3月1日至2020年11月30日期间诊断为新冠肺炎的成年人的出院记录。结果指标包括人口统计学、特征、住院时间、呼吸道插管和机械通气率，以及根据年龄、种族/民族和既往存在的合并症的男性与女性的住院死亡率。在患有新冠肺炎的成年人中，男性为161,206人，女性为146,804人。患有新冠肺炎的成年男性更有可能患有高血压(62.1%vs 59.6%，p<；0.001%)、糖尿病(39.2%vs 36.0%，p<；0.001%)、肾功能衰竭(22.3%vs 18.1%，p<；0.001%)、充血性心力衰竭(15.3%vs 14.6%，p<；0.001%)和肝病(5.9%vs 4.5%，p<；0.001%)。患有新冠肺炎的成年女性更容易肥胖(32.3%比25.7%，p<；0.001)和患有慢性肺部疾病(23.7%比18.1%，p<；0.001)。不同种族的性别差异显著(p<；0.001)，在患有新冠肺炎的非裔美国人患者中，男性比例低于女性比例。与女性相比，患有新冠肺炎的男性患者的住院死亡率(分别为13.8%和10.2%，p<；0.001)、呼吸道插管率(21.4%和14.6%，p<；0.001)以及住院时间(9.5±12.5天和7.8±9.8天，p<；0.001)均高于女性。根据年龄组、种族/民族、付款人和既往存在的合并症进行的住院死亡率分析一致表明，男性的死亡率高于女性(表2)。在所有年龄组中，与患有新冠肺炎的成年男性相比，患有新冠肺炎的成年男性死亡率更高，这种影响在18-30岁年龄组中最为明显(OR，3.02[95%CI，2.41-3.78])。这项对308,010名在美国学术中心住院的新冠肺炎成年人的大型分析显示，与女性相比，男性的呼吸道插管率更高，住院时间更长，即使在不同年龄组、种族/民族、支付者和合并症的情况下也有更高的死亡率。
The coronavirus disease 2019 (COVID-19) pandemic continues to be a global threat, with tremendous resources invested into identifying risk factors for severe COVID-19 illness. The objective of this study was to analyze the characteristics and outcomes of male compared to female adults with COVID-19 who required hospitalization within US academic centers. Using the Vizient clinical database, discharge records of adults with a diagnosis of COVID-19 between March 1, 2020 and November 30, 2020 were reviewed. Outcome measures included demographics, characteristics, length of hospital stay, rate of respiratory intubation and mechanical ventilation, and rate of in-hospital mortality of male vs female according to age, race/ethnicity, and presence of preexisting comorbidities. Among adults with COVID-19, 161,206 were male while 146,804 were female. Adult males with COVID-19 were more likely to have hypertension (62.1% vs 59.6%, p <0.001%), diabetes (39.2% vs 36.0%, p <0.001%), renal failure (22.3% vs 18.1%, p <0.001%), congestive heart failure (15.3% vs 14.6%, p <0.001%), and liver disease (5.9% vs 4.5%, p <0.001%). Adult females with COVID-19 were more likely to be obese (32.3% vs 25.7%, p<0.001) and have chronic pulmonary disease (23.7% vs 18.1%, p <0.001). Gender was significantly different among races (p<0.001), and there was a lower proportion of males versus females in African American patients with COVID-19. Comparison in outcomes of male vs. female adults with COVID-19 is depicted in Table 2. Compared to females, males with COVID-19 had a higher rate of in-hospital mortality (13.8% vs 10.2%, respectively, p <0.001); a higher rate of respiratory intubation (21.4% vs 14.6%, p <0.001); and a longer length of hospital stay (9.5 ± 12.5 days vs. 7.8 ± 9.8 days, p<0.001). In-hospital mortality analyzed according to age groups, race/ethnicity, payers, and presence of preexisting comorbidities consistently showed higher death rate among males compared to females (Table 2). Adult males with COVID-19 were associated with higher odds of mortality compared to their female counterparts across all age groups, with the effect being most pronounced in the 18–30 age group (OR, 3.02 [95% CI, 2.41–3.78]). This large analysis of 308,010 COVID-19 adults hospitalized at US academic centers showed that males have a higher rate of respiratory intubation and longer length of hospital stay compared to females and have a higher death rate even when compared across age groups, race/ethnicity, payers, and comorbidity.
影响因子：
7.3
作者：
Taneja V
通讯作者：
Taneja V
影响因子：
16.6
作者：
Peckham H;de Gruijter NM;Raine C;Radziszewska A;Ciurtin C;Wedderburn LR;Rosser EC;Webb K;Deakin CT
通讯作者：
Deakin CT
影响因子：
158.5
作者：
Price-Haywood, Eboni G.;Burton, M. P. H. Jeffrey;Seoane, Leonardo
通讯作者：
Seoane, Leonardo