Male sex identified by global COVID-19 meta-analysis as a risk factor for death and ITU admission.
Male sex identified by global COVID-19 meta-analysis as a risk factor for death and ITU admission.
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全球COVID-19荟萃分析确定男性为死亡和国际电联入院的风险因素。
DOI：
10.1038/s41467-020-19741-6
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发表时间：
2020-12-09
影响因子：
16.6
通讯作者：
Deakin CT
中科院分区：
文献类型：
--
作者：
Peckham H;de Gruijter NM;Raine C;Radziszewska A;Ciurtin C;Wedderburn LR;Rosser EC;Webb K;Deakin CT
轶事证据表明，由冠状病毒SARS-CoV-2引起的2019冠状病毒病（COVID-19）在发病率和死亡率方面存在性别差异。在这里，我们对全球3，111，714例报告病例进行了荟萃分析，以证明虽然确诊COVID-19的男性和女性比例没有差异，但男性患者需要重症治疗病房（ITU）入院的几率几乎是女性患者的三倍（OR = 2.84; 95% CI = 2.06，3.92）和死亡率（OR = 1.39; 95% CI = 1.31，1.47）高于女性。除了少数例外，在COVID-19中观察到的性别偏见是一个世界性的现象。了解性如何影响COVID-19的结果将对这种疾病的临床管理和缓解策略产生重要影响。传闻报告表明，性别之间感染SARS-CoV-2后的潜在严重程度和结局差异。在这里，作者对从全球公共数据中收集的300多万例病例进行了荟萃分析，以证明患有COVID-19的男性患者需要重症监护的可能性高出3倍，死亡率高出约40%。
Anecdotal evidence suggests that Coronavirus disease 2019 (COVID-19), caused by the coronavirus SARS-CoV-2, exhibits differences in morbidity and mortality between sexes. Here, we present a meta-analysis of 3,111,714 reported global cases to demonstrate that, whilst there is no difference in the proportion of males and females with confirmed COVID-19, male patients have almost three times the odds of requiring intensive treatment unit (ITU) admission (OR = 2.84; 95% CI = 2.06, 3.92) and higher odds of death (OR = 1.39; 95% CI = 1.31, 1.47) compared to females. With few exceptions, the sex bias observed in COVID-19 is a worldwide phenomenon. An appreciation of how sex is influencing COVID-19 outcomes will have important implications for clinical management and mitigation strategies for this disease. Anecdotal reports suggest potential severity and outcome differences between sexes following infection by SARS-CoV-2. Here, the authors perform meta-analyses of more than 3 million cases collected from global public data to demonstrate that male patients with COVID-19 are 3 times more likely to require intensive care, and have ~40% higher death rate.
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