Young age: an independent risk factor for disease-free survival in women with operable breast cancer.
Young age: an independent risk factor for disease-free survival in women with operable breast cancer.
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DOI：
10.1186/1471-2407-4-82
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发表时间：
2004-11-17
期刊：
影响因子：
3.8
通讯作者：
Noh DY
中科院分区：
文献类型：
--
作者：
Han W;Kim SW;Park IA;Kang D;Kim SW;Youn YK;Oh SK;Choe KJ;Noh DY
年轻女性(35岁)的乳腺癌发病率很低。对这一年龄段的疾病生物学了解甚少，与老年患者相比，关于这些女性的预后数据也相互矛盾。我们回顾分析了1990至1999年间在我们机构接受外科手术的2040名连续的原发浸润性乳腺癌患者。年轻组被定义为确诊时年龄为35岁的患者。比较青年组和老年组的临床病理特征和治疗结果。总共有256例(12.5%)患者年龄在35岁以上。与老年患者相比，年轻患者中核3级和髓质组织型肿瘤的发生率明显更高。腋窝淋巴结状态、T分期、组织学分级、c-erbB2表达和雌激素受体状态在两个年龄组之间没有显著差异。在所有时间段，较年轻的患者复发和死亡的可能性都更大。虽然在淋巴结阴性患者中，两个年龄组之间的无瘤生存率没有显著差异，但在淋巴结阳性患者中，年轻组的预后更差(p<；0.001)。在多变量分析中，年轻仍然是复发的显著预测因素(p=0.010)。年轻(35岁)是可手术乳腺癌患者复发的独立危险因素。
The incidence of breast cancer in young women (age < 35) is low. The biology of the disease in this age group is poorly understood, and there are conflicting data regarding the prognosis for these women compared to older patients. We retrospectively analyzed 2040 consecutive primary invasive breast cancer patients who underwent surgical procedures at our institution between 1990 and 1999. The younger age group was defined as patients aged <35 years at the time of diagnosis. The clinicopathological characteristics and treatment outcomes were compared between younger and older age groups. A total of 256 (12.5%) patients were aged <35. There was a significantly higher incidence of nuclear grade 3 and medullary histological-type tumors in younger patients compared to older patients. Axillary lymph node status, T stage, histological grade, c-erbB2 expression and estrogen receptor status did not differ significantly between the two age groups. Younger patients had a greater probability of recurrence and death at all time periods. Although there was no significant difference in disease-free survival between the two age groups in lymph node-negative patients, the younger group showed worse prognosis among lymph node-positive patients (p < 0.001). In multivariate analysis, young age remained a significant predictor of recurrence (p = 0.010). Young age (<35) is an independent risk factor for relapse in operable breast cancer patients.
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影响因子：
45.3
作者：
Choi, DH;Lee, NH;Haffty, BG
通讯作者：
Haffty, BG
影响因子：
168.9
作者：
DELAROCHEFORDIERE, A;ASSELAIN, B;FOURQUET, A
通讯作者：
FOURQUET, A
影响因子：
45.3
作者：
Robson, M;Gilewski, T;Offit, K
通讯作者：
Offit, K
影响因子：
158.5
作者：
ADAMI, HO;MALKER, B;STONE, B
通讯作者：
STONE, B
影响因子：
3.5
作者：
RAVDIN, PM;CHAMNESS, GC
通讯作者：
CHAMNESS, GC