The expressions of MIF and CXCR4 protein in tumor microenvironment are adverse prognostic factors in patients with esophageal squamous cell carcinoma.
The expressions of MIF and CXCR4 protein in tumor microenvironment are adverse prognostic factors in patients with esophageal squamous cell carcinoma.
复制标题
肿瘤微环境中MIF、CXCR4蛋白表达是食管鳞癌患者不良预后因素
DOI：
10.1186/1479-5876-11-60
复制
发表时间：
2013-03-08
影响因子：
7.4
通讯作者：
Li J
中科院分区：
文献类型：
--
作者：
Zhang L;Ye SB;Ma G;Tang XF;Chen SP;He J;Liu WL;Xie D;Zeng YX;Li J
肿瘤源性细胞因子及其受体在肿瘤患者的疾病进展和预后中起着重要作用。在这项研究中，我们旨在检测MIF和CXCR4在不同肿瘤微环境细胞群中的表达水平及其与食管鳞状细胞癌（ESCC）患者生存率的关系。方法采用免疫化学方法检测136例ESCC肿瘤标本中smif和CXCR4水平。采用Pearson 's卡方检验和Cox回归分析进行相关性分析和独立预后分析。结果CXCR4在肿瘤细胞中的表达与肿瘤状态（P= 0.045）、临床分期（P= 0.044）呈正相关；而肿瘤浸润淋巴细胞（til）中CXCR4的表达以及肿瘤细胞和til中MIF的表达与ESCC患者的临床参数无关。肿瘤细胞中MIF或TILs高表达或肿瘤细胞中CXCR4高表达与ESCC患者生存不良有显著相关性（P< 0.05）。多因素分析显示，肿瘤细胞中MIF或CXCR4的表达以及TILs中MIF的表达是影响整个队列患者无病生存期（DFS）和总生存期（OS）的不利独立因素（P< 0.05）。此外，肿瘤细胞中MIF和CXCR4的表达是转移/复发ESCC患者DFS和OS降低的独立因素（P< 0.05）。有趣的是，MIF和CXCR4在肿瘤细胞和TILs中的表达呈显著正相关（P< 0.05）， MIF和CXCR4在肿瘤细胞中的联合表达是DFS和OS的独立不良预测因素（P< 0.05）。结论MIF和CXCR4蛋白在肿瘤细胞和TILs中的表达对ESCC具有不同的临床预测价值。
BackgroundTumor-derived cytokines and their receptors usually take important roles in the disease progression and prognosis of cancer patients. In this survey, we aimed to detect the expression levels of MIF and CXCR4 in different cell populations of tumor microenvironments and their association with survivals of patients with esophageal squamous cell carcinoma (ESCC).MethodsMIF and CXCR4 levels were measured by immunochemistry in tumor specimens from 136 resected ESCC. Correlation analyses and independent prognostic outcomes were determined using Pearson’s chi-square test and Cox regression analysis.ResultsThe expression of CXCR4 in tumor cells was positively associated with tumor status (P= 0.045) and clinical stage (P= 0.044); whereas the expression of CXCR4 in tumor-infiltrating lymphocytes (TILs) and the expression of MIF in tumor cells and in TILs were not associated with clinical parameters of ESCC patients. High MIF expression in tumor cells or in TILs or high CXCR4 expression in tumor cells was significantly related to poor survival of ESCC patients (P< 0.05). Multivariate analysis showed that the expression of MIF or CXCR4 in tumor cells and the expression of MIF in TILs were adverse independent factors for disease-free survival (DFS) and overall survival (OS) in the whole cohort of patients (P< 0.05). Furthermore, the expression of MIF and CXCR4 in tumor cells were independent factors for reduced DFS and OS in metastatic/recurrent ESCC patients (P< 0.05). Interestingly, the expressions of MIF and CXCR4 in tumor cells and in TILs were significantly positively correlated (P< 0.05), and the combined MIF and CXCR4 expression in tumor cells was an independent adverse predictive factor for DFS and OS (P< 0.05).ConclusionThe expressions of MIF and CXCR4 proteins in tumor cells and TILs have different clinically predictive values in ESCC.
登录
查看更多内容
通过靶向哺乳动物雷帕霉素靶点 (mTOR) 途径抑制人胃癌细胞中趋化因子（CXC 基序）配体 12/趋化因子（CXC 基序）受体 4 轴 (CXCL12/CXCR4) 介导的细胞迁移
影响因子：
4.8
作者：
Chen, Guang;Chen, Si-Meng;Meng, Ling-Hua
通讯作者：
Meng, Ling-Hua
影响因子：
20.3
作者：
Kryczek, Ilona;Banerjee, Mousumi;Zou, Weiping
通讯作者：
Zou, Weiping
影响因子：
11.2
作者：
Domschke, Christoph;Schuetz, Florian;Beckhove, Philipp
通讯作者：
Beckhove, Philipp
影响因子：
2.5
作者：
Liao, Bing;Zhong, Bi-Ling;Li, Bin
通讯作者：
Li, Bin
影响因子：
4.2
作者：
Baron, Nina;Deuster, Oliver;Bacher, Michael
通讯作者：
Bacher, Michael