The extracellular matrix provides directional cues for neuronal migration during cerebellar development.
The extracellular matrix provides directional cues for neuronal migration during cerebellar development.
复制标题
细胞外基质为小脑发育过程中的神经元迁移提供方向线索。
DOI：
10.1590/s0100-879x2006000300001
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发表时间：
2006
期刊：
影响因子：
--
通讯作者：
M. Porcionatto
中科院分区：
文献类型：
--
作者：
M. Porcionatto
正常的中枢神经系统发育依赖于准确的内在细胞程序以及由细胞外分子提供的外在信息线索。神经前体细胞从特定的增殖区迁移到其最终位置是胚胎和出生后发育过程中的一个关键事件。细胞外基质成分在这些过程中起着重要作用，神经元与细胞外基质之间的相互作用是中枢神经系统正常发育的基础。指导线索是由定向神经元迁移的细胞外因子提供的。在小脑发育过程中，细胞外基质分子层粘连蛋白和纤维连接蛋白为神经元前体的迁移提供支持，而其他分子如reelin、tenascin和netrin则为其迁移提供方向。Reelin和tenascin是细胞外基质成分，在发育过程中通过与膜受体相互作用吸引或排斥神经元前体和轴突，Netrin与层粘连蛋白和硫酸乙酰肝素蛋白多糖结合，并与神经元表面存在的细胞外基质受体整合素结合。总之，细胞外基质成分组成和分布的动态变化提供了外部线索，指示神经元离开出生地到达正确的最终位置。了解神经元在发育过程中准确定位到最终位置的分子机制是理解神经元错位如何导致神经疾病并最终找到治疗方法的基础。
Normal central nervous system development relies on accurate intrinsic cellular programs as well as on extrinsic informative cues provided by extracellular molecules. Migration of neuronal progenitors from defined proliferative zones to their final location is a key event during embryonic and postnatal development. Extracellular matrix components play important roles in these processes, and interactions between neurons and extracellular matrix are fundamental for the normal development of the central nervous system. Guidance cues are provided by extracellular factors that orient neuronal migration. During cerebellar development, the extracellular matrix molecules laminin and fibronectin give support to neuronal precursor migration, while other molecules such as reelin, tenascin, and netrin orient their migration. Reelin and tenascin are extracellular matrix components that attract or repel neuronal precursors and axons during development through interaction with membrane receptors, and netrin associates with laminin and heparan sulfate proteoglycans, and binds to the extracellular matrix receptor integrins present on the neuronal surface. Altogether, the dynamic changes in the composition and distribution of extracellular matrix components provide external cues that direct neurons leaving their birthplaces to reach their correct final location. Understanding the molecular mechanisms that orient neurons to reach precisely their final location during development is fundamental to understand how neuronal misplacement leads to neurological diseases and eventually to find ways to treat them.
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影响因子：
4.6
作者：
P. Borghesani;J. Peyrin;R. Klein;J. Rubin;Alexandre R. Carter;P. Schwartz;A. Luster;G. Corfas
通讯作者：
P. Borghesani;J. Peyrin;R. Klein;J. Rubin;Alexandre R. Carter;P. Schwartz;A. Luster;G. Corfas
体外连合轴突的方向响应底板衍生的化学引诱剂。
DOI：
10.1242/dev.110.1.19
发表时间：
1990
期刊：
Development (Cambridge, England)
影响因子：
--
作者：
Placzek,M;Tessier-Lavigne,M;Jessell,T;Dodd,J
通讯作者：
Dodd,J
与腱蛋白的相互作用以及对神经组织的两种主要硫酸软骨素蛋白聚糖神经聚糖和磷酸聚糖的细胞粘附的不同影响。
DOI：
--
发表时间：
1994
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Grumet,M;Milev,P;Sakurai,T;Karthikeyan,L;Bourdon,M;Margolis,RK;Margolis,RU
通讯作者：
Margolis,RU
Unc5h3 突变小鼠的胚胎表型表明小脑嘴边界形成过程中存在化学排斥。
DOI：
10.1242/dev.125.1.41
发表时间：
1998
期刊：
Development (Cambridge, England)
影响因子：
--
作者：
Przyborski,SA;Knowles,BB;Ackerman,SL
通讯作者：
Ackerman,SL