Strengthened functional connectivity in the brain during muscle fatigue.
Strengthened functional connectivity in the brain during muscle fatigue.
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DOI：
10.1016/j.neuroimage.2011.12.013
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发表时间：
2012-03
期刊：
影响因子：
5.7
通讯作者：
Yue, Guang H.
中科院分区：
文献类型：
--
作者：
Jiang, Zhiguo;Wang, Xiao-Feng;Kisiel-Sajewicz, Katarzyna;Yan, Jin H.;Yue, Guang H.
由持续次最大强度肌肉收缩引起的疲劳涉及大脑中的激活增加，例如初级运动皮层（M1），初级感觉皮层（S1），前运动和补充运动区（PM&SMA）和前额叶皮层（PFC）。这些皮质区激活水平的同步增加表明，运动控制网络内与疲劳相关的功能耦合加强。在本研究中，这一假设进行了测试，使用基于交叉相关的功能连接（FC）分析方法。10名受试者使用右手以50%最大随意收缩（MVC）力水平进行20分钟间歇性（3.5s开/6.5s关，总共120次试验）抓握任务，同时使用3 T Siemens Trio扫描仪使用回波平面成像（EPI）序列扫描他们的大脑。左侧M1的代表性信号时程通过对局部最大激活灶的相邻体素的2 mm簇的时程数据求平均来提取，所述局部最大激活灶由一般线性模型识别。通过将大脑中所有体素的最小（前10次试验）和显著（后10次试验）疲劳阶段的时程数据与相应的代表性时程交叉相关，为每名受试者创建两个FC激活图。采用直方图和分位数回归分析比较了最小疲劳阶段和显著疲劳阶段的FC，结果表明，多个皮层区域的FC显著增加，包括右侧M1和双侧PM&SMA，S1和PFC。这种增强的FC表明，当肌肉疲劳发生时，许多大脑区域增加了与左侧M1的耦合，右手握柄的主要运动输出控制中心，通过增强下降命令以更大的肌肉募集来维持相同的力量，以协调的方式补偿肌肉产生力量的能力下降。
Fatigue caused by sustaining submaximal-intensity muscle contraction(s) involves increased activation in the brain such as primary motor cortex (M1), primary sensory cortex (S1), Premotor and supplementary motor area (PM&SMA) and prefrontal cortex (PFC). The synchronized increases in activation level in these cortical areas suggest fatigue-related strengthening of functional coupling within the motor control network. In the present study, this hypothesis was tested using the cross-correlation based functional connectivity (FC) analysis method. Ten subjects performed a 20-minute intermittent (3.5s ON/6.5s OFF, 120 trials total) handgrip task using the right hand at 50% maximal voluntary contraction (MVC) force level while their brain was scanned by a 3T Siemens Trio scanner using echo planar imaging (EPI) sequence. A representative signal time course of the left M1 was extracted by averaging the time course data of a 2-mm cluster of neighboring voxels of local maximal activation foci, which was identified by a general linear model. Two FC activation maps were created for each subject by cross-correlating the time course data of the minimal (the first 10 trials) and significant (the last 10 trials) fatigue stages across all the voxels in the brain to the corresponding representative time course. Histogram and quantile regression analysis were used to compare the FC between the minimal and significant fatigue stages and the results showed a significant increase in FC among multiple cortical regions, including right M1 and bilateral PM&SMA, S1 and PFC. This strengthened FC indicates that when muscle fatigue worsens, many brain regions increase their coupling with the left M1, the primary motor output control center for the right handgrip, to compensate for diminished force generating capability of the muscle in a coordinated fashion by enhancing the descending command for greater muscle recruitment to maintain the same force.
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